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9 Cards in this Set
- Front
- Back
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What is aspirins MOA?
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irreversibly inhibits cyclooxygenase - blocking cells ability to make prostaglandins - blocking thromboxane production
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Why is heparin administered along with warfarin?
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Warfarin takes a few days to become effective - those first few days can be hypercoagulable so heparin is administered to avoid coagulation
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What is the difference in the MOA of tPA and streptokinase/urokinase?
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tPA - only activates plasmin that is already bound to fibrin - they will only attack clots that are in the body at that time
strep/uro - activates plasminogen - keep eating clots even when don't have any - can't make clots when we would need them (surgery) |
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What are the 4 classes of antiarrhythmics?
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Silly Bunnies Punch Cats
Sodium channel blocker Beat blocker Potassium channel blocker Calcium channel blocker |
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What is Dobutamine used for? What is coadministered, why?
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it is the DOC for cardiogenic shock
It is too powerful for CHF it is administered with dopamine to prevent reflex vasodilation |
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What are the 4 types of asthma?
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intrinsic - no history of allergy, triggered by severe upper resp infection or by severe, chronic stress
extrinsic - most common - type 1 hypersensitivity (allergy) exercise induced - inadequate sympathetic nervous system activity drug induced - sulfites, beta-blockers, NSAIDs including aspirin |
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What is cromolyn's MOA
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mast cell stabilizer - it blocks the start of the immediate and delayed asthmatic reactions. Yields a block of allergen and exercise-induced bronchoconstriction as well as intrinsic asthma
Only prophylactic |
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How do leukotriene inhibitors help with asthma
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block the effects of leukotrienes (VC and bronchoconstriction)
wont treat the direct cause for asthma but relieve symptoms - used as an adjunct |
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What is omalizumab's MOA?
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monoclonal antibody to IgE - it blocks IgE from binding t hihg-affinity IgE receptors on basophils and mast cells - preventing completion of Type 1 hypersensitivity
SE - anaphylaxis - can be fatal most serious cases of severe persistent asthma |
