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5 Cards in this Set
- Front
- Back
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What is the main component/center to the cytokine cycle?
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CD4 T Cell
Produce IL2 - produce B cells, CD8 T cells, and NK cells Produce IL4/5 - produce B cells Produce INF gamma - produce Monocytes Macrophages (stim by monocytes) produce IL1 which stimulate CD4 T cells to start the cycle |
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What class of HLA antigen is presented on virtually all nucleated cells?
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HLA Class 1
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What effects do INFalpha and INF beta have? Where do each come from?
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anti viral effects - induce MHC 1 to present to T cells and inhibits viral mRNA translation.
alpha - granulocytes, macrophages, T/B cells stim by bone marrow (IL7) beta - fibroblasts |
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Acute phase is induced by?
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IL-1, IL-6, TNF-alpha.
This produces acute phase proteins, CRP, serum amyloid protein, complement, fibrinogen, prothrombin. |
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What starts each of the complement pathways?
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classical - antigen/antibody complexes
Lectin - mannan-containing microbial surface lectin alternate - endotoxins*, cobra venom, complex polysaccharides |
