Boop Bronchiolitis Obliterans Organizing Pneumonia

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BOOP

VS

BO

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bronchiolitis obliterans organizing pneumonia = Cryptogenic organizing pneumonia (COP


Bronchiolitis Obilerans

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Bronchiolitis Obilerans

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histological dx of : inflammatory cells + fibroblasts forming plugs filling :
-bronchioles
-alveloar ducts
-alveoli

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Pathogenesis of Bronchiolitis Obilerans

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a rxn/response to :
-infection
-CTD
-Drugs
-idiopathic ((BOOP))

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cause of Bronchiolitis Obilerans

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--post-infection (viral)
--post-transplantation
--toxins/fumes exposure
--drugs ((penicillamine // gold))
--CTD

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idiopathic BOOP presentation

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subacute illness
1-cough
2-dyspnea
3-fever
4-crackles/squeaks on exam - 75 %
clinical and radiological imaging resemble infectious pneumonia. diagnosis is suspected after no response to multiple antibiotics, and blood and sputum cultures are negative for organisms.

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diagnosis steps

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1-CXR
2-PULM.function test

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CXR

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-patchy infiltrate
-migratory infiltrate
-

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pulm.function test
BOOP vs BO

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BOOP : Restrictive pattern
20 % only show obstruction ....all smoker


BO : obstructive pattern

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the most recent name of BOOP

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Cryptogenic organizing pneumonia (COP

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cryptogenic organizing pneumonia
what

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a type of diffuse interstitial lung disease that affects the distal bronchioles, respiratory bronchioles, alveolar ducts, and alveolar walls [1-7]. The primary area of injury is within the alveolar wall.

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CT scan

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1

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treatment of
1-BOOP
2-BO

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1-BOOP : steroid responsive
dose 0.75-1.5 mg/kg
for 6 months ( to prevent relapse)
2-BO : less responsive/unpredictable to steroids

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1

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1