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11 Cards in this Set
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- Back
- 3rd side (hint)
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Parosteal osteosarcoma
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-large bony mass affixed to cortical surface of long bone
-posterior distal femur most common -histo: well-formed bone in spindled stroma (deceptively bland looking) -lacks osteoblastic rimming -excellent prognosis -middle-aged female -rad: heavily mineralized density attached to cortex, broad base wrapping around bone -CAN dedifferentiate |
looks sort of like fibrous dysplasia but FD has chinese character trabeculae and vessels in the middle
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enchondroma
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-benign neoplasm of hyaline cartilage
-rad: well-circ radiolucency with punctate opacities -lobulated -medullary cavity OR surface -third to fifth decades -metaphyses and diaphyses of small bones of HANDS/FEET |
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polyostotic enchondromas - name of syndrome
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ollier's disease
-greater cellularity, larger cells |
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chondrosarcoma
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-second most common malignant neoplasm of bone in adults
-large bones of axial skeleton (pelvis, scapula, sternum) -rad: endosteal scalloping, cortical thickening, soft tissue mass |
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myxoid chondrosarcoma
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-uncommon: occurs in soft tissue or bone
-histo: monotonous proliferation of uniform smallish cells with brightly acidophilic cytoplasm, cords and sheets within myxoid stroma |
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mesenchymal chondrosarcoma
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-biphasic: well-diff cartilage and small immature mesenchymal cells
-stroma with HPC-like vessels -highly malignant and aggressive -often JAW bones and RIBS of YOUNG ADULTS -rad: destructive lesion |
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chordoma
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-low to intermediate grade
-adults, after sixth decade -sacro-coccygeal region mostly, less often skull -physaliphorous cells have vacuolated cytoplasm and prominent nucleoli, solid sheets/cords/single cells within abundant myxoid stroma -moderate nuclear atypia OK, but mits infrequent -lobulated appearance -local & regional recurrence is high, distant mets rare -rad: solitary, large, central, expansile lucency |
in spine - cervical vertebrae most common, especially in children
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MFH
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-pleomorphic neoplasm of bone
-atypical spindle cells, STORIFORM pattern -usually solitary lesion in long bones -rad: ill-defined radiolucency -femur, tibia, humerus and pelvis most common |
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non-ossifying fibroma
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-benign, in KIDS
-METAPHYSIS of long bones, especially lower extremities -rad: well-defined radiolucency with scalloped margins - metaphysis -aka fibrous cortical defect -no treatment required -histo: few and irregularly dispersed giant cells |
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ossifying fibroma
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-jaw
-third and fourth decades -immature trabeculae with round calcific spherules - CEMENTICLES -OSTEOBLAST rimming is present |
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fibrous dysplasia
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-monostotic and polyostotic forms
-ribs, facial bones, long bones -rad: intramedullary lesion, varying opacity --> "ground glass", expansile, thinning one cortex, WITHOUT soft tissue mass or periosteal reaction -histo: fibrocellular stroma with maloriented CURVILINEAR trabeculae comprised of woven bone -WITHOUT OSTEOBLAST rimming -round calcified cementum-like spherules commonly seen |
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