Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
|
**What must always accompany a bone marrow sample to the lab?
|
CBC results or EDTA blood to do their own CBC
|
|
|
What are 6 conditions that are most often usefully assessed w/ bone marrow exam?
|
1) Non-regenerative anemia
2) Persistent, unexplained neutropenia 3) Persistent thrombocytopenia 4) Unexplained pancytopenia 5) Monoclonal gammopathy 6) Suspicion of primary or metastatic neoplasia in bone marrow |
|
|
What is a reason to do a bone marrow collection in horses?
|
To see if anemia is regenerative or not since horses don't put out reticulocytes when anemic.
|
|
|
What is pancytopenia?
|
Decrease in all 3 cell lines
|
|
|
What are 2 methods of bone marrow collection?
|
1) Bone marrow aspirate
2) Bone marrow core |
|
|
Where can you take bone marrow samples in small animals?
|
Proximal femur
Proximal humerus Iliac crest |
|
|
Where can you take bone marrow samples in large animals?
|
Iliac crest
Sternum Ribs |
|
|
True or false. The periosteum needs a nerve block to perform a bone marrow biopsy.
|
True, where lots of nerves are
|
|
|
There isn't usually a change in pressure when inserting a bone marrow biopsy tool, so how do you know how far to insert the needle?
|
Measure the needle ahead of time
|
|
|
How does bone marrow appear when you take an aspirate?
|
Looks like blood but is bubbly
|
|
|
How can you make a bone marrow smear?
|
Take a syringe and put a drop on a slide and take another slide and place it perpendicular and very carefully spread it out
|
|
|
What are the 3 cell lines we are concerned about in the bone marrow?
|
Erythroid
Myeloid (white cells) Megakaryocytes |
|
|
What's the purpose of preparing a bone marrow slide in house?
|
To make sure that you sampled bone marrow
|
|
|
What do you want to look at on a bone marrow slide?
|
Evaluate cellularity
Look at all three cell lines Look for infectious organisms Look for neoplastic cells Look for erythrophagocytosis Look for plasma cells |
|
|
What is the normal ratio of myeloid: erythroid cells?
|
1:1
|
|
|
What will you see on a bone marrow sample of an animal with leukemia?
|
A homogeneous population of cells
|
|
|
How can you tell if anemia is from an iron deficiency by looking at a bone marrow smear?
|
As hemoglobin is broken down see the golden brown=hemociderin and then as continues to be broke down see this blue/black color
|
|
|
What do plasma cells look like?
|
Large lymphocytes with an eccentric nucleus & more cytoplasm & bluer than a lymphocyte, can see light spot=golgi apparatus
|
|
|
Why can there be plasma cells in the bone marrow?
|
Plasma cells are lymphocytes responding to an antigen so they must be responding to some kind of chronic stimulus-infectious agents like ehrlichia are good at that, could be autoimmune or multiple myeloma
|
|
|
What would immune-mediated hemolytic anemia do to the myeloid: erythroid ratio?
|
Would have a decreased M:E ratio bc bone marrow is producing RBCs that are destroyed in the periphery so increased erythropoiesis
|
|
How would you classify this bone marrow?
|
Hypoplastic marrow
|
|
|
What is hypoplastic marrow?
|
Marrow with a few cells
|
|
|
What is aplastic bone marrow?
|
Essentially the whole area where hematopoietic cells should be have very few cells
-Results in pancytopenia |
|
How would you classify this marrow?
|
Aplastic marrow
|
|
|
What is myelophthisis?
|
Replacement of hematopoietic cells with abnormal tissue-either neoplastic cells or fibrosis
|
|
|
True or false. Once you start getting bone marrow in your needle during a bone marrow aspirate you should keep applying negative pressure.
|
False, then will contaminate the sample with peripheral blood
|
|
|
When should you perform a bone marrow core?
|
When can't get a good aspirate or in cases or marrow fibrosis
|
