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7 Cards in this Set
- Front
- Back
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Name common functions of proteins and examples for each function.
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1) Enzymes: DNA polymerase
2) Structural: Elastin 3) Protein pumps: Multi-drug resistance integral protein 4) Ligands: Insulin 5) Receptors: Insulin receptr 6) Contractile: myosin 7) Carriers: hemoglobin 8) Protective: immunoglobins |
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Name 3 sources of diversity in proteins from genes.
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1) mRNA editing
2) Splicing 3) Post-translation modification |
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What are the 4 levels of Protein structure?
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1) Amino acid sequence
2) Protein folds (helix and sheets) 3) Native/fully folded polypeptide 4) Homo or hetero subunit interactions/holoenzyme |
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What causes emphysema in smokers?
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Oxidation of alpha1-antitrypsin to another compound leads to destruction of elastic fiber and connective tissue in proteins of alveoli b/c of elastase.
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Why can resistance to one drug lead to multi-drug resistance?
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There is an integral membrane protein that can pump out drugs - if you increase number of pumps for one drugs, it will work for other drugs as well.
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How can the multi-drug resistance pump work against cisplatin, the cancer therapeutic?
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Cisplatin normally distorts DNA so that replication cannot be completed and cancer cell dies, but multi-drug res. pump can pump out Cisplatin along with other pumps, rendering it useless.
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What causes defects in 15% of all genetic diseases?
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defects in mRNA splicing
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