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14 Cards in this Set
- Front
- Back
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It has been established that ____________ and ___________can promote or exacerbate cancer.
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Inflamation and infections
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Tumor initiation-definition
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The process by which normal cells become genetically altered to become malignant.
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Tumor Promotion
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Malignant tumor cells are stimulated to grow.
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Tumor Progression
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The process by which the growing tumor becomes more aggressive.
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NFkappaB
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A transcription factor that regulates the expression of many genes whose products can suppress tumor cell death.
It can allow for tumor growth. It can help with tumor invasiveness. |
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Activation of these can also enhance tumor development.
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TLRs
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Potent inducers of tumor cell death.
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TRAIL
IL-10 TGF-beta |
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The cell cycle is largely regulated by these.
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Cyclin and cyclin-dependant kinases.(CDk4)
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p53 gene
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A tumor suppressor gene.
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IL-6 activates this.
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JAK/STAT
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TNF-alpha activates this.
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NFkappaB
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These are 'tumor promoting'
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TNFalpha
IL6 IL17 |
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These are 'tumor destroying'
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TRAIL
IL10 IL12 |
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What is immunotherapy?
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The mech. by which the host immune system is activated and transfer immune cells, or Ab, or cytokines into the host.
The host becomes more effective in rejecting the tumor. Not the side effects of chemo or radiation therapies. |
