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15 Cards in this Set

  • Front
  • Back
Condyloma acuminatum: what is it?
Genital warts caused by HPV

"Papillomatous pedunculated or sessile growths with a roughened keratotic surface"
Condyloma acuminatum: caused by which HPV types?
Non-dysplastic lesions: HPV 6, 11

Dysplastic lesions: HPV 16, 18, 31, 33, 35
Condyloma acuminatum: microscopic
Koilocytes! Dark chromatin with a clear nucleus.
Koilocytes
HPV infection
Penile squamous cell carcinoma in situ: types
1. Erythroplasia of Queyrat
2. Bowen's Disease
3. Bowenoid Papulosis
How does the histology of the below compare?

1. Erythroplasia of Queyrat
2. Bowen's Disease
3. Bowenoid Papulosis
The histology is identical. All squamous cell carcinoma in situ.
1. Erythroplasia of Queyrat
2. Bowen's Disease
3. Bowenoid Papulosis

Site?
EQ: Glans
BD: Shaft
BP: Shaft
1. Erythroplasia of Queyrat
2. Bowen's Disease
3. Bowenoid Papulosis

Age?
1. Erythroplasia of Queyrat (50-60)
2. Bowen's Disease (40-50)
3. Bowenoid Papulosis (30-40)
1. Erythroplasia of Queyrat
2. Bowen's Disease
3. Bowenoid Papulosis

Gross?
1. Erythroplasia of Queyrat: erythematous plaque

2. Bowen's Disease: Grayish-white plaque

3. Bowenoid Papulosis: papules
1. Erythroplasia of Queyrat
2. Bowen's Disease
3. Bowenoid Papulosis

Histology?
All carcinoma in situ
1. Erythroplasia of Queyrat
2. Bowen's Disease
3. Bowenoid Papulosis

Progress to invasive type?
1. Erythroplasia of Queyrat (10%)
2. Bowen's Disease (5-10%)
3. Bowenoid Papulosis (None!)
1. Erythroplasia of Queyrat
2. Bowen's Disease
3. Bowenoid Papulosis

Spontaneous regression?
1. Erythroplasia of Queyrat (none)
2. Bowen's Disease (none)
3. Bowenoid Papulosis (yes)
Invasive squamous cell carcinoma of the penis: demographics
Uncommon in the US (< 1% of cancer in males), but very common in Asian, African, and Latin American countries
Invasive squamous cell carcinoma of the penis: risk factors
1. Phimosis --> bad hygiene --> exposure to carcinogens

2. HPV infection (50% of invasive SCC patients have HPV infection)

3. Smoking
Invasive squamous cell carcinoma of the penis: microscopic
See keratinized pearls just like you would anywhere else.