Bocock Uworld Week 3.3

Front 1

Neurofibromatosis type 1 has what type of inheritance?

Back 1

autosomal dominant

Front 2

cafe-au-lait spots, neurofibromas, and lisch nudules?

Back 2

neurofibromatosis type 1

Front 3

Small intestinal and colonic atresias occur due to...?

Back 3

vascular obstructions in utero

Front 4

"Apple peel" atresias are associated with...?

Back 4

obstruction of the SMA

Front 5

Bile acid binding resins(cholestyramine) are unique among hypolipidemia agents in that they....?

Back 5

increase blood TGs

Front 6

Formula for positive predictive value?

Back 6

a/a+b

Front 7

Formula for NPV?

Back 7

d/d+c

Front 8

What two epidemiological parameters vary as the prevalance of a disease changes?

Back 8

PPV and NPV

Front 9

Nerve responsible for extension of hand...damage causes wrist drop?

Back 9

radial nerve

Front 10

Damage to this nerve in the shoulder region affects opposition of the thumb?

Back 10

median nerve

Front 11

Damage to what nerve would affect thumb adduction?

Back 11

ulnar nerve

Front 12

Mitochondrial enzyme that activates caspases and causes cell death through intrinsic pathway apoptosis?

Back 12

cytochrome C

Front 13

Org associated with gas gangrene and late onset food poisoning that can cause a transient watery diarrhea?

Back 13

clostridium perfringens

Front 14

Orgs associated with early onset food poisoning caused by performed toxins?

Back 14

(1) staph aureus
(2) Bacillus cereus

Front 15

The spores of this gram + bacillus are abundant in soil?

Back 15

clostridium Perfringens

Front 16

The most common form of congenital adrenal hyperplasia is due to a deficiency in.....?

Back 16

21 hydroxylase

Front 17

21 hydroxylase converts what to reactions to make mineralcorticoids and glucocorticoids?

Back 17

(1) progesterone--> 11 deoxycorticosterone

(2) 17 OH progesterone--> 11 deoxycortisol

Front 18

With undescended testes, the seminiferous tubules will be affected. What hormone will likely be decreased in this pt?

Back 18

inhibin

Front 19

MCC of hypocalcemia?

Back 19

primary hypoparathyroidism

Front 20

What is a common cause of primary hypoparathyroidism?

Back 20

thyroid surgery

Front 21

Classic lab finding in pts with thalessemia?

Back 21

hypochromic, microcytic anemia

Front 22

What type of virus is hepatitis E?

Back 22

non-enveloped single stranded RNA virus

Front 23

Most concerning feature of hepatitis E infection?

Back 23

high mortality rate seen in infected pregnant woman

Front 24

What hepatitis viruses are transmitted by the fecal-oral route?

Back 24

hep a and e

Front 25

Hep E causes an acute illness and is not associated with.....?

Back 25

chronic infection

Front 26

Current alzheimer disease treatments?

Back 26

(1) cholinesterase inhibitors-->donepezil

(2) antioxidants--> alpha tocopherol

(3)NMDA receptor antagonists--> memantine

Front 27

HIT is treated with....?

Back 27

direct thrombin inhibitors

Front 28

Direct thrombin inhibitors used to rx HIT?

Back 28

(1) argatroban
(2) hirudin
(3) lepirudin

Front 29

Warfarin MOA?

Back 29

blocks vit k dependant glutamate residue carboxylation

Front 30

Inhibit Plt aggregation by inhibiting PDE activity and increasing Camp?

Back 30

dipyridamole and cilostazol

Front 31

Seen in pap smear specimens from woman with bacterial vaginosis caused by gardnerella vaginalis?

Back 31

clue cells

Front 32

Hallmark of HPV infection?

Back 32

koilocytosis

Front 33

These are immature squamous cells with a dense, irregularly staining cytoplasm and perinuclear clearing-assoc with HPV infection?

Back 33

koilocyte

Front 34

Common football injury with force to the lateral side of the knee causes damage to the....?

Back 34

(1)medial collateral ligament
(2)anterior cruciate ligament
(3)lateral meniscus

Front 35

Autoantibodies to hemidesmosomes?

Back 35

bullous pemphigoid

Front 36

Autoantibodies to desmosomes?

Back 36

pemphigus vulgaris

Front 37

Many noncaseating granulomas in organs and tissues in a young black woman w. bilateral hilar lymphoadenopathy?

Back 37

sarcoidosis

Front 38

Org that causes pharyngitis and pseudomembrane in the throat?

Back 38

corynebacterium diptheriae

Front 39

Immunization with diptheria toxoid induces production of...?

Back 39

circulating IgG against the exotoxin B subunit

Front 40

What subunit of the corynebacteriia diptheriae AB toxin is the binding subunit?

Back 40

the B subunit

Front 41

What is the formula for a 95% confidence interval?

Back 41

CI=mean+or-Z*SEM

note:
sem=standard error of the mean=SD/square root n

Z=z score=1.96

Front 42

For a 99% confidence interval, the z score is....?

Back 42

z=2.58

Front 43

characterized by sxs of schizophrenia in the presence of mood sxs?

Back 43

schozoaffective disorder

Front 44

Posterior neck tumors that are apparent at birth in infants w/ turner's sydrome?

Back 44

cystic hygromas

Front 45

Associated with swelling of the hands and feet (lymphedema) and posterior neck cystic hygromas at birth?

Back 45

turner's syndrome

Front 46

Characteristic appearance of turner's syndrome in the adult?

Back 46

(1) webbed neck
(2) low hairline
(3) shield chest
(4) short stature

Front 47

round face+cat like cry+ microcephaly

Back 47

cri du chat syndrome

Front 48

short stature+primary ammenorrhea+coarctation of the aorta

Back 48

tuner's syndrome

Front 49

MC site of gastric tumors?

Back 49

lesser curvature of the stomach

Front 50

what arteries run along the lesser curvature of the stomach and are likely to be damaged by ulcers?

Back 50

L and R gastric arteries

Front 51

Presents with shearing or tearing chest pain that radiates to the back?

Back 51

aortic dissection

Front 52

Type of microcytic anemia where RBCs are unable to incorporate iron into heme?

Back 52

sideroblastic anemia

Front 53

Agents used to rx acute asthma exacerbations?

Back 53

beta 2 adrenergic agonists

Front 54

Ace inhibitor angiodema is due to an increase in what molecule?

Back 54

bradykinin

Front 55

dephosphorylates glycogen synthase promoting glycogen formation?

Back 55

protein phosphatase

Front 56

This enzyme is stimulated by insulin and results in glycogen formation and inhibition of gluconeogenesis?

Back 56

protein phosphatase

Front 57

Used to analyze mRNA?

Back 57

northern blot

Front 58

used to analyze DNA sequences?

Back 58

southern blot

Front 59

Strongly associated with anal and cervical squamous cell carcinoma?

Back 59

HPV 16, 18, and 31

Front 60

Another name for phosphatidylcholine?

Back 60

lecithin

Front 61

commonly used to measure fetal lung maturity in the amniotic fluid?

Back 61

lecithin/sphengomyelin ratio

Front 62

What happens to albumin CONCENTRATIONS in a pregnant woman from early gestation to term?

Back 62

decrease by 50%

Front 63

What receptors are bound by the HIV envelope protein Gp 120 and allow the virus to enter cells?

Back 63

CD4 and CCR5

Front 64

A deletion in both alleles that code for this receptor results in resistance to HIV infection?

Back 64

CCR5

Front 65

CA drugs that are nephrotoxic and cause acoustic nerve damage?

Back 65

cisplatin and carboplatin

Front 66

CA drug that causes peripheral neuropathy?

Back 66

vincristine

Front 67

CA drug that causes pulmonary fibrosis?

Back 67

bleomycin

Front 68

CA drug that causes cardiotoxicity?

Back 68

doxorubicin

Front 69

CA drug that causes hemorrhagic cystitis

Back 69

cyclophosphomide

Front 70

What drugs inhibit dihydrofolate reductase?

Back 70

trimethoprim, methotrexate, and pyrimethamine

Front 71

Obligate intracellular bugs that cannot make their own ATP?

Back 71

rickettsia and chlamydia

Front 72

Facultative intracellular bugs?

Back 72

"Some Nasty Bugs May Live FacultativeLY"
salmonella, neisseria, brucella, mycobacterium, listeria, francisella, legionella, yersina pestis