Bocock Uworld Week 2.3

Front 1

Ribosomes attached to the RER synthesize what type of proteins?

Back 1

secretory, membrane bound, and lysosomal proteins

Front 2

These are welll developed in protein secreting cells?

Back 2

RER

Front 3

Function of the SER?

Back 3

steroid synthesis and drug detoxification

Front 4

Surface marker specific for macrophages?

Back 4

CD 14

Front 5

B cell surface marker?

Back 5

CD 20

Front 6

A deficiency in what enzyme causes Niemann Pick Disease?

Back 6

sphingomyelinase

Front 7

Probability that someone with a positive test willl truely have a disease?

Back 7

Positive predictive value (a/a+b)=TP/TP+FP

Front 8

In normal individuals, the O2 saturation should be the same in what areas of the heart?

Back 8

the atria and the ventricles

Front 9

The most common congenital heart defect that creates a L to R shunt?

Back 9

ventricular septal defect (VSD)

Front 10

Most likely heart defect if there is an increase in O2 saturation between the RA and the RV?

Back 10

left to right shunt....VSD

Front 11

Produces a holosystolic murmur that is loudest over the left mid sternal border?

Back 11

VSD

Front 12

Produces a continous systolic and diastolic machinary like murmur?

Back 12

patent ductus arteriosis

Front 13

Visual impairment in an HIV patient?

Back 13

CMV retinitis

Front 14

RX for cytomegalovirus induced retinitis?

Back 14

ganciclovir, foscarnet, and cidofovir

Front 15

Used to rx CMV infection in an HIV pt but causes hypocalcemia and hypomagnesemia?

Back 15

foscarnet

Front 16

Most common site of urinary obstruction (hydronephrosis) in a fetus?

Back 16

ureteropelvic junction(junction between the kidney and the ureter)

Front 17

Describes an obstruction of the cystic duct or common bile duct by a gallstone?

Back 17

choledocolithiasis

Front 18

Abdominal pain and distention, vomiting, tenderness to palpation, and tinkling bowel sounds are characteristic of what finding?

Back 18

small bowel obstruction

Front 19

Occurs in pts with a hx of gallstones where a gs causes an obstruction at the ileocecal valve?

Back 19

gallstone ileus

Front 20

What would be seen on x-ray with gallstone ileus?

Back 20

air in the gallbladder and biliary tree

Front 21

Group A beta hemolytic streptococci?

Back 21

streptococcus pyrogenes

Front 22

Major virulence factor for group A beta hemolytic step. pyrogenes that inhibits phagocytosis?

Back 22

M protein

Front 23

Total resistance of a parallel circuit?

Back 23

1/TPR= 1/r1+ 1/r2+ 1/r3...

Front 24

Describes blood flow in an individual organ?

Back 24

series circuit
TPR=R1+R2+R3

Front 25

LOW levels of alpha fetoprotein (AFP) are associated with what condition?

Back 25

Trisomy 21

Front 26

Conditions associated with HIGH alpha fetoprotein?

Back 26

(1) multiple gestation
(2) neural tube defects
(3) abdominal wall defects

Front 27

RX used for heparin overdose?

Back 27

protamine sulfate

Front 28

Emetic rx that is valuable IMMEDIATELY following ingestion of a poison?

Back 28

syrup of ipecac

Front 29

Rat poison =

Back 29

warfarin

Front 30

RX for a patient who has ingested rat poison?

Back 30

fresh frozen plasma (replenishes coag factors 2,7,9, and 10)

Front 31

Multiple ring enhancing lesions in an HIV patient?

Back 31

toxoplasmosis

Front 32

Pulmonary function test findings in a patient with emphysema?

Back 32

(1) decreasd FEV1/FVC
(2) increase in total lung volume
(3) decreased diffusing capacity

Front 33

Exits the skull through the foramen ovale and innervates the muscles of mastication?

Back 33

mandibular nerve (CNV3)

Front 34

DOC for absence seizures?

Back 34

ethosuximide or sodium valproate

Front 35

Maturing erythrocytes lose their ability to synthesize Heme when they lose what organelle?

Back 35

mitochondria

Front 36

What is missing in severe combined immunodeficiency?

Back 36

adenosine deaminase (adenosine is toxic to B and T cells)

Front 37

Triad of cerebellar defects (ataxia), spider angiomas (telangiactasia), with IgA deficiency?

Back 37

ataxia telangiectasia

Front 38

Combination of thrombocytopenic purpura, infections, and eczema with a decrease in IgM?

What is the mode of inheritance?

Back 38

Wiskott Aldrich syndrome

x-linked recessive

Front 39

Recurrent bacterial infections, absent pus formation, and delayed separation of the umbilicus?

What is the defect?

Back 39

leukocyte adhesion deficiency

missing integrins

Front 40

Combination of partial albinism, recurrent resp tract and skin infections, with neurological disorders (seizures and peripheral neuropathy)?

What is the defect?

Back 40

chediak-higashi syndrome

defective lysosomal transport gene

Front 41

Recurrent bacterial infections after 6 months, affects Boys, and a decrease in all classes of immunoglobulins?

Back 41

Brutons agammaglobulinemia

Front 42

Tetany (hypocalcemia), recurrent viral/fungal infections with congenital heart and great vessel defects?

What pharyngeal pouches fail to develop?

Back 42

digeorge syndrome (thymic aplasia)

3rd and 4th pharyngeal pouches

Front 43

Presents with eczema, reccurent cold abcesses, coarse facial features, and retained primary teeth?

What is the defect?

Back 43

Job's syndrome (hyper IgE syndrome)

Th cells fail to make IFN gamma-->inability of neutrophils to respond to chemotactic stimuli

Front 44

Candida albicans infections of the skin and mucous membranes?

What is the rx?

Back 44

chronic mucocutaneous candidiasis

ketoconazole

Front 45

Which hormones use steroid recpetors?

Back 45

(1)estrogen
(2)progesterone
(3)testosterone
(4)aldosterone
(5)Vitamin D
(6) T3 and T4
(7) glucocorticoids

Front 46

Which hormones use tyrosine kinase receptors?

Back 46

(1)Insulin
(2)IGF-1
(3)FGF
(4)PDGF
(5)prolactin
(6)GH

Front 47

What factors are required for H. influenzae to grow on agar?

Back 47

factors X (hematin) and V (NAD+)

Front 48

When H. influenzae grows near B hemolytic S. aureus on agar?

Back 48

satellite phenomenon

Front 49

Group of drugs associated with rhabdomyloysis and are metabolized by the P450 enzyme system?

Back 49

statins

Front 50

Only statin not metabolized by P450?

Back 50

pravastatin

Front 51

rx for opoid intoxication

Back 51

naloxone

Front 52

rx for benzodiazepine overdose?

Back 52

flumazenil

Front 53

rx for acute neonatal narcotic withdrawal?

Back 53

tincture of opium

Front 54

Number of true positives divided by the total number of subjects WITH a disease?

Back 54

sensitivity (a/a+c)

Front 55

The number of true negatives divided by the total number of subjects WITHOUT a disease?

Back 55

specificity (d/d+b)

Front 56

What artery delivers blood to the medial portions of the two hemispheres of the brain?

What defects would be seen upon occlusion?

Back 56

anterior cerebral arteries

deficits to contralateral legs

Front 57

Used for heart failure and causes hyperkalemia through its action on the Na/K Atpase pump?

Back 57

digoxin

Front 58

Abnormalities seen in tetralogy of fallot?

Back 58

(1) pulmonic stenosis
(2) VSD
(3) RV hypertrophy
(4) overriding aorta

Front 59

The degree of R to L shunting in TOF depends on the severity of what defect?

Back 59

severity of pulmonic stenosis