Bocock Uworld Week 1.6

Front 1

The only cortisol producing tumor that is suppressed by dexamethasone?

Back 1

ACTH producing pituitary tumor

Front 2

Symptoms of 21 B hydroxylase deficiency?

Back 2

(1) HYPOtension

(2) masculinization

Front 3

Symptoms of 11 B hydroxylase deficiency?

Back 3

(1) HYPERtension

(2) masculinization

Front 4

Effect of cortisol on........

(1) Bone

(2) Immune system

Back 4

(1) reduces bone formation (osteoporosis)

(2) suppresses the immune system

Front 5

Tumors associated with MEN 1?

Back 5

(1) Pituitary

(2) parathyroids

(3) Pancreas

The 3 P's!!!

Front 6

Tumors associated with MEN 2A?

Back 6

medullary thyroid tumor, pheochromocytoma, and
parathyroids

Front 7

Tumors associated with MEN 2B?

Back 7

medullary thyroid tumor, pheochromocytoma, and mucosal neuromas/GI tumors

Front 8

Cancers associated with the RET GENE mutation?

Back 8

MEN 2A, MEN 2B, papillary thyroid CA, and medullary thyroid CA

Front 9

Part of sarcomere that contains actin only?

Back 9

I band

Front 10

Lies in the center of the I band in thr sarcomere?

Back 10

Z lines

Front 11

Anchored to the Z line of the sarcomere?

Back 11

actin

Front 12

Center of the sarcomere where myosin is bound?

Back 12

M line

Front 13

Region of the sarcomere where actin does not overlap with myosin?

Back 13

I band

Front 14

G protein involved in the MAP kinase signal transduction pathway?

Back 14

RAS protein

Front 15

RAS g protein becomes active when it binds to what molecule?

Back 15

GTP

Front 16

Oxygenated blood from the placenta is delivered to the fetus via...

Back 16

the umbilical vein

Front 17

Contains the highest oxygen content in the fetal circulation?

Back 17

umbilical vein from the placenta

Front 18

Blood in the umbilical vein bypasses the hepatic circulation via this structure?

Back 18

ductus venosus

Front 19

Remnant of the umbilical vein in the adult?

Back 19

ligamentum teres

Front 20

Remnant of the ductus venosus in the adult

Back 20

ligamentum venosum

Front 21

Delivers deoxygented blood from the fetus back to the placenta?

Back 21

umbilical arteries

Front 22

Blood pumped into the pulmonary circulation may bypass the lungs through this structure?

Back 22

ductus arteriosis

Front 23

Adult remnant of the ductus arteriosis?

Back 23

ligamentum arteriosum

Front 24

The most highly oxygented blood in the fetus is carried by this structure?

Back 24

umbilical vein

Front 25

The umbilical vein empties directly into the....

Back 25

inferior vena cava via the ductuc venosus

Front 26

The ability of a test to IDENTIFY those with a given disease?

Back 26

sensitivity

Front 27

Ability of a test to EXCLUDE those from having a disease?

Back 27

specificity

Front 28

Calculate sensitivity

Back 28

a/a+c= TP/TP+FN

Front 29

Calculate specificity

Back 29

b/b+d= TN/TN+FP

Front 30

Should be monitored in patients taking the class 3 AA amiodarone?

Back 30

Thyroid function (TSH)

Front 31

5 side effects of amiodarone?

Back 31

(1) Thyroid dysfunction

(2) corneal microdeposits

(3) Blue-gray skin discolorization

(4)Hepatitis

(5) Pulmonary fibrosis

Front 32

Neutrophils fail to turn blue upon nitroblue tetrazolium testing?

Back 32

hallmark test for CGD

Front 33

Enzyme that forms ROS in neutrophil phagolysosomes?

Back 33

NADPH oxidase

Front 34

Deficiency in NADPH oxidase?

Mode of inheritance?

Back 34

(1) chronic granulomatous disease

(2) x linked

Front 35

Patients with CGD cannot kill....

Back 35

catalase positive orgs

Front 36

Results in fibrin coating of S.aureus and resistance to phagocytosis?

Back 36

coagulase

Front 37

Orgs with polysaccharide capsules?

Back 37

H influenzae and S. pneumoniae

Front 38

Gas gangrene

Back 38

clostridium perfringens

Front 39

Enzyme responsible for gas gangrene seen with clostridium perfringens?

Back 39

Lecithinase

Front 40

Region of the sarcomere containing ONLY myosin thick filaments?

Back 40

H band

Front 41

Bands of the sarcomere that decrease during contraction?

Back 41

H and I bands

Front 42

DNA mutation that introduces a STOP codon?

Back 42

nonsense mutation

Front 43

Deletion or insertion of base pairs which are not a multiple of three result in...

Back 43

frameshift mutations

Front 44

Moves more slowly toward the anode (+ end) than HbA and HbS on hemoglobin electrophoresis?

Back 44

HbC

Front 45

Nonpolar valine replaces negatively charged glutamic acid in both beta chains?

Back 45

HbS

Front 46

Lysine is substuted for glutamate?

Back 46

HbC

Front 47

DNA mutation that results in a changed amino acid?

Back 47

missense mutation

Front 48

Heart sound associated with increased LV end diastolic pressure?

Back 48

Third heart sound (S3)

Front 49

Third heart sound (S3) present in older adults?

Back 49

LV failure

Front 50

Decreased LV wall compliance (stiff ventricle)?

Back 50

S4 heart sound

Front 51

Required for vesicle to release their contents into the synaptic cleft?

Back 51

calcium

Front 52

Responsible for the upstroke in the AP in the SA node?

Back 52

calcium

Front 53

This ion is resposible for the upstroke of the AP in skeletal muscle, smooth muscle, and cardiac muscle?

Back 53

sodium

Front 54

Drugs that inhibit the metabolism of warfarin and increase the risk of bleeding?

Back 54

cyp inhibitors

Front 55

Delivers motor innervation to the diaphram?

Back 55

phrenic nerve (c3-c5)

Front 56

Motor innervation to the sternocleidomastoid and trapezius muscles?

Back 56

spinal accesory nerve (CN XI)

Front 57

Will cause sharp pain on inspiration in the C3-C5 distribution?

Back 57

irritation of parietal pleura

Front 58

Carries PAIN fibers from the mediastinal and diaphragmatic pleura?

Back 58

phrenic nerve (c3-c5)

Front 59

Blotchy red muscle fibers on Gomori trichome stain?

Back 59

mitochondrial disease

Front 60

"RED Ragged" muscle fibers?

Back 60

mitochondrial disease

Front 61

Probability that a male will pass on a mitochondrial disease to his offspring?

Back 61

0%

Front 62

Mitochondrial diseases have what type of inheritance?

Back 62

maternal inheritance

Front 63

Grows on charcoal yeast extract agar with cysteine?

Back 63

legionella pneumophila

Front 64

health care workers can be nasal carriers of this org?

Back 64

MRSA

Front 65

Contaminates water and establishes infection by the pulmonary route?

Back 65

Legionella pneumophila

Front 66

Doing what is best for the patient?

Back 66

beneficience

Front 67

White plaques on oral mucosa?

Back 67

oral thrush
(candida albicans infection)

Front 68

Present in bird and bat droppings?

Back 68

histoplasma capsulatum

Front 69

cave exploror

Back 69

histoplasma capsulatum

Front 70

Oral thrush in a healthy patient?

Back 70

think HIV infection

Front 71

Common cause of infertility?

Back 71

anovulation

Front 72

Acts like FSH and stimulates the formation of a dominant ovarian follicle?

Back 72

menotropin

Front 73

Injected to stimulate LH surge?

Back 73

hCG

Front 74

Sxs of adrenal insufficiency?

Back 74

vomiting, abdominal pain, weight loss, and hyperpigmentation

Front 75

Treatment of anaphylaxis, severe asthma, and cardiac arrest?

Back 75

epinephrine

Front 76

Used in the treatment of shock and refractory cardiac failure

Back 76

dopamine

Front 77

Immediate Rx for adrenal crisis?

Back 77

corticosteroids

Front 78

Rotator cuff is made up of the tendons of what 4 muscles?

Back 78

(1) supraspinatus

(2) infraspinatus

(3) Teres minor

(4) subscapularis

(SITS)

Front 79

Most common injured structure in rotator cuff injury

Back 79

tendon of the supraspinatus muscle

Front 80

Important side effects of the thiazlidinediones (TZDs) like pioglitazone and rosiglitazone?

Back 80

Liver injury and fluid retention