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38 Cards in this Set
- Front
- Back
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CD2
on what cell(s), and what is function |
t cells, thymocytes, NK cells
adhesion molecule |
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CD3
on what cell(s), and what is function |
T cells, Thymocytes
signal transduction by TCR |
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CD4
on what cell(s), and what is function |
TH hells, thymocytes, monocytes, and Macrophages
Coreceptor for TCR-MHC II interaction, Receptor for HIV |
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CD8
on what cell(s), and what is function |
CTLs, some thymocytes
coreceptor for MHC class I restricted T cells |
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CD14
on what cell(s), and what is function |
monocytes, macrophages, granulocytes
Binds LPS |
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CD16
on what cell(s), and what is function |
AKA Fc receptor
Nk cells, macrophages, PMNs opsonization ADCC (antibody dependent cell-mediated cytotoxicity |
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CD18
DZ? on what cell(s), and what is function |
Leukocytes
cell adhesion molecule DZ = leukocyte adhesion deficiency |
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CD19
on what cell(s), and what is function |
B cells
coreceptor with CD 21 for B cell activation |
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CD20
on what cell(s), and what is function |
most or all B cells,
role is uknown |
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CD21
DZ? on what cell(s), and what is function |
Mature B cells
aka c3d receptor receptor for complement fragment c3d, forms coreceptor complex with CD19 EBV receptor! |
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CD25
on what cell(s), and what is function |
activated TH and Treg cells
alpha chain of IL2 receptor |
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CD28
on what cell(s), and what is function |
T cells
T cell receptor for costimulatory molecule B7 |
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CD34
on what cell(s), and what is function |
precursors of hematopoietic cells,
endothelial cells in HEV - high endothelial venules - cuboidal to allow lymphocytes in |
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CD40
on what cell(s), and what is function |
B cells, macrophages, dendritic cells, endothelial cells
Binds Cd40L, role in T cell dependent B cell, macrophage, dendritic cell and endothelial cell activation |
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CD56
on what cell(s), and what is function |
NK cells
role unknown |
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CD152
on what cell(s), and what is function |
activated t cells
negative regulation competes with CD 28 for B7 binding |
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IL1
what is it secreted by |
monocytes, macrophagtes, b cells, dendritic cells, endothelial cells
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IL1 - what does it do?
TO: TH cells B cells NK cells Endothelial cells Macs and PMNs Hepatocytes Hypothalamus |
major inflamatory cytokine -
Stimulates TH cells Promotes maturation and clonal expansion of B cells Enhances NK activity Increas expression of ICAMs by Endo cells Chemotactic attraction of Macs and PMNs induces synthesis of acute phase proteins induces fever |
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IL2
secreted by? target? activity |
secreted by TH cell
target - antigen primed TH and CTLs induces proliferation, enhances activity |
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IL3
secreted by? target? activity |
secreted by TH cells, NK cells
Target- hematopoietic cells (pluripotent -->myeloid cell) supports growth and differentiation FYI myeloid cell produces all cell types except lymphocytes |
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IL4
secreted by? target? activity |
secreted by Th2 cells
Target - antigen primed B cells - to costimulate activation Target - activated B cells - stimulate prolif and differentiation, INDUCE CLASS E switch |
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IL 5
secreted by? target? activity |
secreted by Th2 AND mast cells
target - activated B cells - stimulate prolife and differentiation CLASS SWITCH TO IgA!!! Target - bone marrow - induce EOSINOPHIL diff |
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IL6
secreted by? target? activity |
From Monos, Macs, Th2 cells, bone marrow
Target - Proliferating B cells - Promotes diff INTO PLASMA CELLS target - Plasma cell - stim Ab prod |
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IL7
secreted by? target? activity |
From bone marrow, thymic stromal cell
Target - lymphoid stem cells Induces diff into progenitor B and T cells! |
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IL8
secreted by? target? what other cytokines are similar |
From Macs and endo cells
Target - PMNs Chemokine - induce adherence to Endo and extravasation into tissue Similar to N-formyl peptides from bacteria and C5a compliment degredation product |
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IL10
secreted by? target? activity |
from TH2 and T reg cells
Target - Macs Suppress cytokine production by Th1 TH1 Suppressor! |
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IL11
secreted by? target? activity |
by bone marrow and stroma
Target - bone marrow To increase PL count |
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IL12 - two jobs
secreted by? target? activity |
From Macs and B cells
Target - activated CD8+ cells Acts synergistically with IL2 to diff into CTLs And from NK cells and activated TH1 - to stim proliferation |
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IL13
secreted by? target? activity |
From Th2 cells
Target - B cells Induces isotype switch to IgE |
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IL17
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From TH17 cells
Target - fibroblasts, endo cells, and MAc action - increase Inflam, Attract PMNs, induce IL6, IL1 TGFbeta, TNFalpha, and IL8 |
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Interferon Alpha (type I)
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From leukocytes
Inhibits Viral replication |
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Interferon Beta (type I)
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from fibroblasts
inhibits viral replication |
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interferon Gamma - 4 roles
secreted by? target? activity |
From - Th1, CTLs, NK cells
Targets Macs - enhance activity increase cell expression of MHC class 1 and 2 Proliferating B cells - induce switch to IgG2a, AND blocks IL4-Induced switch to IgE and IgG1 Target - TH2 cells - to INHIBIT target - Phago cells - mediate effect TREATMENT FOR CGD, and important in DTH? |
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Transorming growth factor Beta
TGFbeta |
From PLs, macs, lymphs, and mast cells
Target - Proliferation B cells induces class switch to IgA! |
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TNF alpha
secreted by? target? activity |
From Macs and NK cells
Target - tumor cells - cytotoxic activity Target inflam cells - induce cytokine secretion, causes cachexia of chronic inflamation |
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Tumor necrosis factor Beta
TNFbeta |
From Th1 and CTLs
Target tumor cells - cytotoxic effect Target - macs and PMNs - enhance phago activity |
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Granulocyte colony stimulating factor
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from Macs and TH cells -
Target - BM graculocyte precures Induce prolif Used clinically to counteract neutropenia following ablative Chemo |
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Granulocyte-macrophage colony stimulatin factor
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From macs and TH cells
Target BM and Mac precursors - induce prolif of macs and target neutorpenia from chemotherapy |
