Boards Immunology

Front 1

IMMUNOLOGY

Back 1

IMMUNOLOGY

Front 2

Lymph Node (FA 222)

1) Site of B-cell localization in lymph node?

2) Part of lymph node where you can find medullary cords packed w/ lymphocytes and plasma cells AND where you can find macs?

3) Part of the Lymph node w/ all the T-cells?

Back 2

1) Follicle

2) Medulla

3) Paracortex

Front 3

1) What does the R. lymphatic duct drain?

2) What does the thoracic duct drain?

Back 3

1) R. arm
R. half of head
R. chest
Lower lobe of lung?

2) Everything else

Front 4

1) Where in the spleen are T-cells found?

2) Where in the spleen are B-cells found?

3) What type of bacteria are killed off in the spleen?

4) What are 2 types of RBCs that can be seen post-splenectomy?

5) What happens to thrombocytes post-splenectomy?

Back 4

1) PALS

2) Follicles / Germinal Centers

3) Encapsulated bacteria (SHiN SKIs)

4) Howell-Jolly Bodies
Target Cells

5) Thrombocytosis

Front 5

1) Where do T-cells mature?

2) Where do B-cells mature?

Back 5

1) Thymus

2) Bone Marrow

Front 6

1) What does this describe:
PRO on the surface of a cell that are CODED FOR by the HLA GENES?

2) MHC I is assoc w/ what T-cells?

3) MHC II is assoc w/ what T-cells?

Back 6

1) MHCs

2) CD4 Th cells

3) CD8 Tc cells

Front 7

What Cond'ns are the following HLA subtypes assoc w/:

1) HLA-A3

2) HLA-B27

3) HLA DR3

4) HLA DR4

Back 7

1) Hemochromatosis

2) PAIR:
Psoriasis, Ankylosing Spondylitis, IBD, Reiter's Syndrome

3) T1 DM

4) RA and T1 DM

Front 8

NK cells are lymphocytes that are stimulated by what 3 cytokines?

Back 8

IL-12
IFN-beta
IFN-alpha

Front 9

1) In the differentiation of T-cells, where does positive selection take place? (T-cells must express TCRs that bind to MHC, in order to survive)

2) In the differentiation of T-cells, where does negative selection take place? (T-cells expressing TCRs that bind self-Ag undergo apoptosis)

Back 9

1) Thymic cortex

2) Corticomedullary jnctn

Front 10

SEE PIC SHOWING TC AND TH INTERACTING W/ APC

Back 10

SEE PIC SHOWING TC AND TH INTERACTING W/ APC

Front 11

1) Th1 cells secrete what 2 cytokines?
A) What cytokines inhib Th1?

2) Th2 cells secrete what 3 cytokines?
A) What cytokine inhibits Th2 cells?

Back 11

1) IL-2, IFN-gamma
A) IL-10 from Th2 cells

2) IL-4, IL-5, IL-10
A) IFN-gamma from Th1 cels

Front 12

In order to kill cells, Tc cells release what 2 substance which contribute to apoptosis?

Back 12

perforin
granzyme

Front 13

What part of an Ab determines its isotype (IgG, IgA, etc...)?

Back 13

Constant region Fc

Front 14

Which Ab Isotype does this describe:

-Crosses Placenta
-MOST abundant in blood
-Secondary, Delayed response to Ag

Back 14

IgG

Front 15

What Ab Isotype does this describe?:

-2 forms: a monomer in circulation and a dimer when secreted
-In secretions (tears, saliva, mucus)
-In breast milk

Back 15

IgA

Front 16

What Ab Isotype does this describe?:

-Involved in primary immediate response to Ag
-A pentamer

Back 16

IgM

Front 17

What Ab Isotype does this describe?:

Found on surface of many b-cells in the serum

Back 17

IgD

Front 18

What Ab Isotype does this describe?:

-Binds mast cells and basophils
-Mediates Type 1 HS

Back 18

IgE

Front 19

What 2 additional components does Secretory IgA have?

Back 19

- J-Chain
-Secretory component

Front 20

Which components of complement comprise the MAC (membrane attack complex) -->
Cell lysis

Back 20

C5b-C9

Front 21

Recurrent Neisseria infxns should make you knee-jerk what?

Back 21

C5-C8 complement deficiency

Front 22

What do the following cytokines do:

1) IL-1
2) IL-2
3) IL-3
4) IL-4
5) IL-5

Back 22

1) Fever
2) stim T-cells
3) stim Bone marrow
4) stimi igE and IgG production
5) stim igA and eosin production

Front 23

Which cytokine is chemotactic for PMNs?

Back 23

IL-8

"clean up on AISLE 8"

Front 24

What are 2 pro-inflamm cytokines?

Back 24

IL-10
TGF-beta

Front 25

Which cytokine activates macs?

Back 25

IFN-gamma

Front 26

Name That Hypersensitivity:

Ag + IgE + MC or Bast -->
Histamine Release

First and Fast
Anaphylactic and Atopic

Back 26

Type I HS

Front 27

Name That Hypersensitivity:

Self-cells + IgG or IgM + Phagocytosis or C' Activation

Cytotoxic
Direct and Indirect coombs
Transfusion RXN
Hyperacte-T-plan rejection

Back 27

T II HS

Front 28

Name That Hypersensitivity:

Immune complex (Ag + IgG) deposition --> Complement activation

Serum Sickness
Arthus RXN
Goodpastures (anti-GBM)

Back 28

Type III HS

Front 29

Name That Hypersensitivity:

T-cell + Ag --> Lymphokines released --> Stim Macs

Poison Ivy

Back 29

Type IV HS

Front 30

Auto-Ab

Back 30

Auto-Ab

Front 31

ANA

Back 31

SLE (non-specific)

Front 32

Anti-dsDNA

Back 32

SLE

Front 33

Anti-Smith

Back 33

SLE

Front 34

Anti-histone

Back 34

Drug induced lupus

Front 35

Anti-IgG (Rheumatoid Factor)

Back 35

RA

Front 36

anti-Centromere

Back 36

CREST sCleroderma

Front 37

anti-Scl-70 (anti-DNA Topoisomerase I)

Back 37

Scleroderma (Diffuse)

Front 38

Anti-mitochondiral

Back 38

Primary biliary cirrhosis

Front 39

Antigliadin

Back 39

Celiac (Gluten / Gliadin Intol)

Front 40

Anti-endomysial

Back 40

Celiac (Gluten / Gliadin Intol)

Front 41

Anti-basement membrae

Back 41

(Goodpastures)

Front 42

Anti-desmoglein

Back 42

Pemphigus Vulgaris

Front 43

Anti-microsomal

Back 43

Hashimotos Thyroiditis

Front 44

Anti-Thyroglobulin

Back 44

Hashimotos Thyroiditis

Front 45

Anti-Jo-1

Back 45

Polymyositis
Dermatomyositis

Front 46

anti-SS-A (anti-Ro)

Back 46

Sjogren's Syndrome

Front 47

anti-SS-B (anti-La)

Back 47

Sjogren's Syndrome

Front 48

Anti-U1 RNP (RibonucleoPRO)

Back 48

Mixed CT Dz

Front 49

Anti-smooth muscle

Back 49

Autoimmune Hepatitis

Front 50

Anti-glutamate decarboxylase

Back 50

T1 DM

Front 51

c-ANCA

Back 51

Wegener's Granulomatosis

Front 52

1) p-ANCA

2) MPO -ANCA

Back 52

1) Churg Strauss
Microscopic Polyangitis

2) pauci-immune crescintic glomerulonephritis

Front 53

Delayed separation of umbilicus

Back 53

LAD from defect in LFA-1 integrins

Front 54

Recurrent bacterial infxns
No thymus shadow

Back 54

Brutons agammaglobulinemia
From
X-linked recessive defect in BTK gene -->
Dec tyrosine kinase

Front 55

Sinus and lying infxns
Anaphylaxis who. Exposed to IgA

Back 55

Selective IgA Defic

Front 56

Tetany
Viral and fungal infxns
No thymic shadow

Back 56

Digeorge syndrome
(thymic Aplasia)
From
22q11 deletion -->
Failure of 3rd and 4th pharyngeal pouches to develop -->
No thymus or PT-->
Dec t cells and ca

Front 57

Disseminated mycobacterium infxns

Back 57

IL-12 receptor deficiency

Front 58

Disseminated mycobacterium infxns

Back 58

IL-12 receptor deficiency

Front 59

FATED:
coarse Facies
cold staph Abscesses
retained primary Teeth
inc iGe
Derm problems

Back 59

Hyper IgE
(jobs syndrome)
-->
Dec IFN-gamma -->
Inability of neutrophils to respond to chemotactic stimuli

Front 60

T-Cell dysfnctn -->
Candida albicans infxns

Back 60

Chronic mu cutaneous candidiasis infxn

Front 61

B and t cell Defic
No thymic shadow
Adenosine delaminates Defic

Back 61

SCID

Front 62

Ataxia
Snider angiomas (Telangiectasias)
Eyes can't follow finger

Back 62

Defective ATM gene which codes for DNA repair enzymes -->
Ataxia Telangiectasia from IgA defic

Front 63

TIE
thrombocytopenia Purpura
Infxn
Eczema

Dec IgM

Back 63

Wiskott Aldrich
(x linked recessive)

Front 64

Cherish higashi?

Back 64

see notes

Front 65

Inc susceptibility to catalase positive organisms

Lack of NADOH oxidase -->
Dec ROS

NEGATIVE NITROBLUE TETRAZOLIUM DYE REDUCTION TEST
(- = blue/black
+ = yellow)

Back 65

Chronic Granulomatous Disease

Front 66

DID NOT INCLUDE INFO IN TRANSPLANT REJECTION SEE FA 239 IF YOU WANT TO SEE

Back 66

DID NOT INCLUDE INFO IN TRANSPLANT REJECTION SEE FA 239 IF YOU WANT TO SEE