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73 Cards in this Set
- Front
- Back
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karyorrhexis
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DNA fragmentation
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karyolysis
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nuclear fragmentation
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coagulative necrosis happens in
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heart
liver kidney |
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liquefactive necrosis happens in
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brain
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caseous necrosis happens in
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tb
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fat necrosis happens in
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pancreas
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fibrinoid necrosis happens in
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blood vessels
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gangrenous necrosis happens in
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limbs
GI |
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transudate or exudate:
which has more cells? which is due to increased pressure which is due to inflammation which is due to lymphatic obstruction |
exudate
transudate exudate exudate |
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what do all of the following do:
catalase superoxide dismutase glutathione peroxidase Vitamins E and A |
free radical degradation
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Type of amyloid in primary amyloidosis
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AL (L is for light chain), which is derived from Ig light chains
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type of amyloid in secondary amyloidosis
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AA, which is derived from serum amyloid-associated protein (SAA), from chronic inflammatory disease)
AA=Acute-phase reactant |
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type of amyloid in senile cardiac amyloidosis
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transthyretin
derived from AF AF is for old Fogies |
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type of amyloid in DM2
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amylin
derived from AE AE is for Endocrine |
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type of amyloid in medullary cancer of the thyroid
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A-CAL
derived from calcitonin A-CAL is for CALcitonin |
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type of amyloid in Alheimers
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Amyloid percursor protein (APP)
derived from beta-amyloid |
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type of amyloid in dialysis-associated amyloidosis
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beta2 microglobulin
derived from MNC class I protetins |
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neoplasm associated with Down syndrome
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ALL
(we all fall down) |
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neoplasm associated with pernicious anemia
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gastric adenocarcinoma
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neoplasms associated with tuberous sclerosis
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astrocytoma
agniomyolipoma cardiac rhabdomyoma |
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neoplasm associated with Barrett's esophagus
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esophageal adenocarcinoma
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neoplasm associated with Plummer vinson
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squamous cell carconima of esophagus
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neoplasm associated wtih cirrhoses
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hepatocellular carcionoma
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neoplasms assocaited with acanthosis nigricans
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SLUB
Black Skin Under Limb visceral malignancies of stomach, lung, breast, uterus |
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bcl2
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follicular and undifferentiated lymphomas
(inhibits apoptosis) |
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ret
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MEN II and III
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c-kit
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GIST
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N-myc
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neuroblastoma
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location of Rb
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13
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location of BRCA1
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17
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location of BRCA2
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13
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location of p53
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17
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location of p16
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9
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location of APC
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5
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location of WT1
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11
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location of NF1
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17
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location of NF2
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22
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location of DPC
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18
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location of DCC
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18
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Rb
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retinoblastoma
osteosarcoma |
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BRCA1
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breast
ovarian |
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BRCA2
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breast
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p53
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most human cancers
Li-Fraumeni |
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p16
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melanoma
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DPC
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pancreatic cancer
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DCC
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colon cancer
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prostatic acid phosphatase
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marker for prostate carcinoma
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alpha fetoprotein
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hepatocellular carcinoma
germ cell tumors of testis (yolk sac tumor) |
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S100
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melanoma
neural tumors astrocytomas |
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alk phos
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clean it up with a MOP
mets to bone obstructive biliary disease Paget's disease |
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CA19-9
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pancreatic adenocarcinoma
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aflatoxins
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hepatocellular carcinoma
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vinyl chloride
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liver (angiosarcoma)
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CCL4
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liver (centrilobular necrosis, fatty change)
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nitrosamines
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esophagus
stomach |
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cigarette smoke
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Lighting Tobacco Ruins Lungs
larynx lung renal cell carcinoma transitional cell carcinoma |
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asbestos
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mesothelioma
bronchogenic carcinoma |
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arsenic
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skin
squamous cell carcionma |
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nphthalene (aniline) dyes
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bladder (transitional cell carcinoma)
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alkylating agents
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blood (leuemia)
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hormone from SCLC
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ACTH or ACTHlike (Cushings)
ADH (SIADH) |
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paraneoplastic from:
squamous cell lung carcinoma renal cell carcinoma breast carcinoma |
Tumor PIT
PTH related peptide TGF beta TNF IL1 causing hypercalcemia |
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paraneoplastic from renal cell carcinoma
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epo (polycythemia)
PTH-related, TGFbeta, TNF, IL1 (hypercalcemia) |
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paraneoplastic from hemangioblastoma
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epo (polycythemia)
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neoplasms with cushing's
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SCLC
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neoplasms with SIADH
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SCLC
intracrnial neoplasms |
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neoplasms with hypercalcemia
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Some Big Rocks
SCLC renal cell carcinoma breast crcionma |
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neoplasms with polycythemia
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renal cell carcinoma
hemangioblastoma |
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neoplasms with Lambert-eaton (muscle weakness)
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thymoma
SCLC (mediated by antibodies agains tpresynaptic Ca++ channels |
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neoplasms with gout and urate nephropathy
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leukemias and lymphomas (mediated by excess nucleic acid turnover
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psammoma bodies associated with
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PSaMMoma
papillary (thyroid) Serous (ovary) Meningioma Mesothelioma |
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mets to brain
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Lots of Bad Stuff Kills Glia
Lung Breast Skin Kidney GI |
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mets to liver
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Cancer Sometimes Penetrates Benign Liver (in order)
Colon Stomach Pancreas Breast Lung |
