Board Review Vasculitis

Front 1

What size vessels does polyarteritis nodosa involve?

Back 1

medium sized vessels

Front 2

What infection is associated with polyarteritis nodosa?

Back 2

Hepatitis B

Front 3

What age/gender patients are typically affected with polyarteritis nodosa?

Back 3

Middle-aged men.

Front 4

What are the key microscopic pathologic findings in polyarteritis nodosa?

Back 4

immunoglobulin and complement deposits in the walls of involved vessels

Front 5

What body systems are typically involved with polyarteritis nodosa?

Back 5

Renal, cardiac, GI, pulmonary, neurologic, cutaneous, musculoskeletal, ocular, genitourinary (anything that can have medium size vessel occlusion)

Front 6

What are typical angiographic finidings of polyarteritis nodosa?

Back 6

fine arborization of visceral vasculature, corkscrewing and wall irregularities, microaneurysms of medium sized vessels

Front 7

What are treatment options for polyarteritis nodosa?

Back 7

ORAL STEROIDS! cytotoxic drugs (cyclophosphamide, chlroambucil, azathioprine, methotrexate, cyclosporine)

Front 8

What is the prognosis for untreated polyarteritis nodosa?

Back 8

Potentially fatal.

Front 9

What is the hallmark immunologic feature of microscopic polyangiitis?

Back 9

anti-myeloperoxidase antibodies (p-ANCA)

Front 10

What types of blood vessels are affected by microscopic polyangiitis?

Back 10

small vessels--arterioles, venules, capillaries

Front 11

What age/gender patient is usually affected by microscopic polyangiitis?

Back 11

Average age=50, male 2:1 female

Front 12

What organ systems are affected by microscopic polyangiitis?

Back 12

Renal, pulmonary, musculoskeletal, cutaneous, GI, ocular.

Front 13

Biopsy findings in microscopic polyangiitis?

Back 13

necrotizing vasculitis with few or no immune deposits

Front 14

What skin finding is most common in microscopic polyangiitis?

Back 14

palpable purpura

Front 15

Treatment for microscopic polyangiitis?

Back 15

high dose steroids and cytotoxic agents (usually cyclophosphamide)

Front 16

What is the major immunologic finding in Wegener's granulomatosis?

Back 16

positive c-ANCA due to antiserine protease 3 antibodies

Front 17

What age/gender patient is usually affected by Wegener's granulomatosis?

Back 17

Men=women; adults of any age.

Front 18

What organ is the most commonly affected in Wegener's granulomatosis?

Back 18

Upper airway (90%).

Front 19

What size vessels are affected in Wegeners' granulomatosis?

Back 19

Small and medium

Front 20

What organ systems are affected in Wegeners' granulomatosis?

Back 20

RESPIRATORY (upper and lower)!!!! renal, musculoskeletal, cutaneous, neurologic, GI, cardiac, GU

Front 21

What are 2 key physical exam findings of Wegener's granulomatosis?

Back 21

Saddle-nose deformity (necrosis of nasal cartilage), perforation of nasal septum.

Front 22

What is the key renal pathologic finding in Wegener's?

Back 22

pauci-immune glomerulonephritis (80%)

Front 23

What radiologic findings can you see on CXR in Wegener's?

Back 23

pulmonary infiltrates, pulmonary nodules

Front 24

What are some typical cutaneous manifestations of wegener's?

Back 24

palpable purpura, cutaneous ulcers, pyoderma gangrnosum, raynaud's

Front 25

Prognosis of untreated wegener's?

Back 25

Uniformly fatal (18% 12 month survival)

Front 26

What is the key immunologic finding in Churg-Strauss syndrome?

Back 26

p-ANCA against antimyeloperoxidase

Front 27

Cardinal features of Churg-Strauss Syndrome?

Back 27

Asthma, allergic rhinitis, fever, hypereosinophilia, systemic vasculitis.

Front 28

Who does Churg-Strauss Syndrome affect?

Back 28

Men 2:1 Women, adults

Front 29

What organ system is primarily involved in CSS?

Back 29

Pulmonary!!!!

Front 30

What are key lab findings in CSS?

Back 30

increased IgE, eosinophilia, pANCA

Front 31

Red flag for CSS

Back 31

Adult-onset asthma

Front 32

Most common neurologic manifestation of CSS

Back 32

ischemic optic neuritis

Front 33

What size vessels are affected by CSS?

Back 33

Small

Front 34

What is the old name for Giant-cell arteritis?

Back 34

Temporal arteritis

Front 35

What size vessels are affected by giant-cell arteritis?

Back 35

large

Front 36

What is the most common form of systemic vasculitis?

Back 36

Giant cell arteritis

Front 37

What is the prognosis of Giant cell arteritis?

Back 37

Good. Typically self limited.

Front 38

What age/gender is typically affected by giant cell arteritis?

Back 38

Female 2:1 Male
>50 years old

Front 39

Biopsy findings in giant cell arteritis?

Back 39

mononuclear cell cell infiltration, giant cell formation, intimal thickening of large vessels

Front 40

Treatment for giant cell arteritis?

Back 40

steroids

Front 41

Major findings in Takayasu's arteritis?

Back 41

granulomatous inflammation of the aorta and its major branches

Front 42

What age/gender is typically affected in Takayasu's arteritis?

Back 42

Women of childbearing years, particularly of Asian ancestry

Front 43

What size vessels are typically involved in Takayasu's arteritis?

Back 43

Large.