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42 Cards in this Set
- Front
- Back
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HLA-A3
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Hemochromatosis
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HLA-B27
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Psoriasis, Ankylosing spondylitis, Inflammatory bowel disease, Reiter's syndrome (PAIR)
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HLA-B8
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Graves' disease
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HLA-DR2
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Multiple sclerosis, hay fever, SLE, Goodpasture's
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HLA-DR3
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Diabetes mellitus type 1
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HLA-DR4
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Rheumatoid arthritis, diabetes mellitus type 1
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HLA-DR5
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Pernicious anemia-->B12 deficiency, Hashimoto's thyroiditis
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HLA-DR7
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Steroid-responsive nephrotic syndrome
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2 primary opsonins in bacterial defense
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C3b and IgG
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An endogenous pyrogen. Causes fever, acute inflammation. Activates endothelium to express adhesion molecules; induces chemokine secretion to recruit leukocytes.
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IL-1
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An endogenous pyrogen. Also secreted by Th cells. Causes fever and stimulates production of actue-phase proteins.
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IL-6
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Major chemotactic factor for neutrophils
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IL-8 (clean up on aisle 8)- Neutrophils are recruited by IL-8 to clear infections
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Induces differentiation of T cells into Th1 cells. Activates NK cells. Also secreted by B cells.
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IL-12
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Mediates septic shock. Activates endothelium. Causes leukocyte recruitment, vascular leak
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TNF-alpha
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Supports the growth and differentiation of bone marrow stem cells. Functions like GM-CSF.
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IL-3
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Stimultaes growth of helper and cytotoxic T cells
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IL-2
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Activates macrophages and Th1 cells. Suppresses Th2 cells. Has antiviral and antitumor properties
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Interferon-gamma
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Induces differentiation into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG.
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IL-4
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Promotes differentiation of B cells. Enhances class swithcing to IgA. Stimulates the growth and differentiation of eosinophils
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IL-5
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Modulates inflammatory response. Inhibits actions of activated T cells and Th1. Activates Th2. Also secreted by regulatory T cells
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IL-10
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Antinuclear antibodies (ANA)
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SLE, nonspecific
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Anti-dsDNA, anti-Smith
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SLE
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Antihistone
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Drug-induced lupus
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Anti-IgG (rheumatoid factor)
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Rheumatoid arthritis
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Anticentromere
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Scleroderma (CREST)
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Anti-Scl-70 (anti-DNA topoisomerase I)
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Scleroderma (diffuse)
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Antimitochondrial
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Primay biliary cirrhosis
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Antigliadin, antiendomysial
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Celiac disease
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Anti-basement membrane
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Goodpasture's syndrome
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Anti-desmoglein
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Pemphigus vulgaris
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Antimicrosomal, antithyroglobulin
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Hashimoto's thyroiditis
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Anti-Jo-1
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Polymyositis, dermatomyositis
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Anti-SS-A (Anti-Ro)
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Sjogren's syndrome
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Anti-SS-B (anti-La)
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Sjogren's syndrome
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Anti-U1 RNP (ribonucleoprotein)
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Mixed connective tissue disease
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Anti-smooth muscle
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Autoimmune hepatitis
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Anti-glutamate decarboxylase
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Type 1 diabetes mellitus
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c-ANCA
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Wegener's granulomatosis
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p-ANCA
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Other vasculitides
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Deficiency of C5-C8 leads to:
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Neisseria bacteremia
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Help prevent complement activation on self-cells
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Decay-accelerating factor (DAF) and C1 esterase inhibitor
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Antigen-presenting cells (APCs)
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Macrophage, Dendritic cell, B-cell
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