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17 Cards in this Set
- Front
- Back
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where are articulated joints? |
knee hip |
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what is primary Osteoarthritis? |
slow progressive loss of ECM and chongrogenic phenotype in articular cartilage |
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What about cartilage changes with age in OA? |
less PG less aggrecan/in pieces |
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DMM = ? |
Destabilisation of Medial Meniscus |
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More catabolism than synthesis of aggrecan or collagen? |
collagen: shown to have greater role i OA when mutations were made in aggrecan/collagen at cell specific site where they interact with ECM |
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which gene is a member of TGF-beta family in ECM Homeostasis? |
GDF5 |
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what is RUNX2 ? |
mast transcription factor that drive endochondrial ossification including MMP-13 expression |
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What genes encoded PTHrp driven by IHH secretion? |
PTHLH |
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What is SMAD3 protein involved in? |
intracellular signalling involved in TGF-beta production |
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What is the cause of RA ? |
immune mediated damage |
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which HLA is RA linked to? |
HLA-DR4 |
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RA is characterised by inflammation of synovium due to ..? |
presence of specific B cell and CD4TH cell mediated by autoimmunity |
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What effect do cytokines have on fibroblasts? |
leads to MMP and RANK Ligand production |
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What do Osteoclasts to? |
destroy bone in joint |
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What are the possible autoAg? |
collagen (CIA) agrecan (PGIA) |
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What does INFLIXIMAB do? |
binds TNFalpha and blocks its action |
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What does RITUXIMAB do? |
It is specific for CD20 and kills B cells |
