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19 Cards in this Set
- Front
- Back
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What type of polio virus has been eradicated?
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Type 2
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-Asymptomatic in 90% = Primary source of spread
-Mild fever, vomitting, viral meningitis |
Polio presentation
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Only 0.5--1% develop this from polio.
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paralytic poliomyelitis
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Polio has reach anterior horn cells
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spinal polio
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Polio has reach brain stem
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bulbar polio (major COD)
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A child fully recovered from polio. 20 years later, she developed the same symptoms...why?
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Polio can be recurrent. Extra branching of focal areas of infections were weak and died.
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A person recieved a vaccine for polio, but then developed polio. How?
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Polio can develop from the vaccine strains especially those who are immunocomprimised.
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Spread of polio?
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Fecal Oral:
Food, water, fingers, utensils |
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What is paradoxical about the epidemiology of polio?
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1. Lowest incidence in overcrowded, poor sanitation environment.
2. Epidemics occurred as sanitation improved. 3. Asymptomatics infectious. |
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What is Salk and Sabin vaccines?
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Salk - Killed vaccine for polio
Sabin = LIVE vaccine for polio |
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Which vaccine for polio prevents fecal-oral spread of wild type, but
may lead to minor/major disease (including VAPP)? |
Sabin (live)
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Which vaccine for polio is non-toxic, does not prevent spread of wild type?
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Salk (Killed)
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What are the 3 strategies for polio vaccines?
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1. Multi dose of Sabin
2. 2X Salk, 2X of Sabin 3. 4X Salk |
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Countries with continuing disease prevalence: “National Immunization Days”
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Multiple dose of Sabin
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Countries w/o polio, but with continued environmental presence of WILD-type virus.
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Two doses Salk, followed by 2 doses Sabin
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Countries where polio viruses have been eradicated.
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Four doses Salk
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does NOT interrupt transmission
(sabin or salk)? |
Salk
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Induces intestinal IgA :-(
[sabin or salk]? |
sabin
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induces cell mediated immunity
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Sabin
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