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20 Cards in this Set
- Front
- Back
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PostTranslation Addition of Glucose to Beta Chain
Increase with Increase Blood Glucose (Diabetes) |
Hemoglobin A1C
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Alter Solubility
Alter Stability Alter Function |
Hemoglobinopathy
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Amino Acid Substitution
Polymer of Insoluble Rigid Aggregate of Hemoglobin Hemolytic Anemia Hemoglobin C Hemoglobin S |
Hemoglobinopathy
Alter Solubility |
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Hemoglobin F
Newborn |
50 to 80 %
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Hemoglobin F
6 Month |
8 %
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Hemoglobin F
> 6 Month |
1 to 2 %
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Most Common Symptomatic Hemoglobinopathy
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Sickle Cell Anemia
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Nonpolar Valine Substitute Polar Glutamic Acid at 6 Position of Beta Chain
Beta 6 Glu to Val |
Sickle Cell Anemia
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Solubility of Hemoglobin S is Reduce in Deoxygenate State
Crescent |
Sickle Cell Anemia
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Autosplenectomy
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Sickle Cell Anemia
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Vaso Occlusive Crisis
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Sickle Cell Anemia
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Infarction
Aseptic Necrosis (Femoral Head) Dactylitis Priaprism |
Sickle Cell Anemia
Vaso Occlusive Crisis |
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Bacterial Infection (Post Autosplenectomy)
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Sickle Cell Anemia
Death |
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Temporary Cessation of Erythropoiesis in Chronic Hemolysis
Worsen Anemia |
Sickle Cell Anemia
Aplastic Crisis |
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Chest Syndrome
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Sickle Cell Anemia
Death in Children |
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Normochromic Normocytic Anemia
Reticulocytosis Nucleate Erythrocyte |
Sickle Cell Anemia
Laboratory |
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Basophilic Stippling
Howell Jolly Body Siderocyte |
Sickle Cell Anemia
Laboratory Splenic Hyofunction |
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Hemoglobin Electrophoresis
Solubility Test Sickling Test DNA PCR (Mutation) |
Sickle Cell Anemia
Diagnosis |
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Aplastic Crisis
Splenic Sequestration |
Sickle Cell Anemia
Therapy Transfusion |
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Hydration
Prophylaxis (Infection) |
Sickle Cell Anemia
Therapy Vaso Occlusion |
