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10 Cards in this Set
- Front
- Back
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Eluate of Fya not responsive after 1 week, why?
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Not buffered correctly
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A cells, O cells, I cells, i cells all 2+. Ficin treated cells all neg. What is antibody? What would you do to prove it?
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anti-Pr
Neuraminidase treat cells |
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Glycophorins for MNSs and the structure of M and N
N-like structure after formaldehyde trm silent allele, involves MNSs only involves MN |
Ss=glycophorin B; MN=glycophorin A
M= ser-ser-thr-thr-gly N=leu-ser-thr-thr-glu; anti-N(f) M(k) silent allele = M-N-S-s- M(g) rare = M-N- (doesn't involve Ss) |
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Anti-U
Given mom & dad MNSs phenotype, they produce an En(a-) child. What is kid's phenotype? |
Can be adsorbed/eluted by S-s cells.
Red cells lack most or all of GPA=En(a-) so kid M-N-Wr(a-b-) just have to figure out Ss from mom & dad. |
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pt R1R2Fy(a-b-)K-k+ and antibody reacts w/13 of 20 or 65% of rbc what is antibody? anti-Rh7 (Ce), anti-K, anti-Cob, or anti-Doa
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anti-Rh7 = >67%
anti-K = 9% anti-Cob = 10% anti-Doa = 67% whites have ag - answer is Doa |
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antibody reacts 1+ with Rh null cells; Fy(a-b-) cell are neg; Fya+ cells are 2+ what is the antibody?
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anti-Fy3
(anti-Fy5 would react with Fy(a-b-) cells) |
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paragloboside + ? = p
paragloboside + ? = P1 globoside + ? = P globoside + ? = Pk Tja |
NeuAc
Gal GalNac Gal PP1Pk |
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What phenotype has trouble concentrating urine?
What antibody would you pick up with polyspecific coombs? |
Jk(a-b-)
Jka |
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Mom is K+k-. What kind of outcome would make you question Ko gene?
Antibody that is non-reactive with Jsa, Jsb, Kpa do not react with these cells? |
1 child K-k+
Ko cells (Ko phenotype is null and makes anti-Ku) |
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anti-Ku gives negative reactions with?
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Ko phenotype.
McLeod phenotype lack Kx & Km. Km & Kx are high incidence ag on all RBC except McLeod. Ko cells lack Km but express Kx. Kx- rbc assoc. w/CGD/WBC dysfunction. |
