Blood Drugs

Front 1

What is a thrombic disorders?

Back 1

myocardial infection, deep vein thrombosis, pulmonary embolism, acute ischemic stroke

Front 2

Define Hemophilia, and what to treat it with?

Back 2

Inherited disorder where blood doesnt clot normally. Factor VIII and Vit K

Front 3

Prostacyclin and Nitric oxide are synthesized by? and function

Back 3

endothelial cells. Inhibitors of platelet aggregation

Front 4

Where do platelets adhere when the vessel is injured ? and what happens

Back 4

to the underlying subendothelial collagens. they adhere and secrete chemical mediators

Front 5

which chemical mediators do platelets secrete.

Back 5

Thrombin Thromboxane Serotonin PAF ADP

Front 6

Ca2+ increase in platelets makes

Back 6

platelets to release granules that activates other platelets

Front 7

Action of ADP and Serotonin

Back 7

activates GP IIb/IIIa receptor that bind fibrinogen aggregates platelets

Front 8

Action of Thrombin

Back 8

Fibrinogen ---> Fibrin
which stabilizes the clot

Front 9

what is Plasmins function

Back 9

it dissolves the fibrin network
as wounds heal

Front 10

Cox-1 is converting?

Back 10

arachidonic acid to PG(h2) that leads to thromboxane A2

Front 11

Aspirin is a prophylactic treatment in

Back 11

transient cerebral ischemia
decreases pre and post Myocardial infarctions

Front 12

Aspirin often us together with ?

Back 12

Heparin and Clopidogrel

Front 13

What is Celecoxib ?

Back 13

its a COX-2 inhibitor
does not interfere with aspirin

Front 14

What is Abciximab ?

Back 14

monoclonal antibody + joined human immunoglobulin
blocks GP IIb/IIIa receptor

Front 15

Abciximab can be given intravenously together with ?

Back 15

Heparin and Aspirin

Front 16

2 drugs similar to Abciximab

Back 16

Eptifibatide

Front 17

a drug treat thrombotic complications
ex acute coronary

Back 17

Abciximab Eptifibatide Tirofiban

Front 18

Dipyridamole is a

Back 18

coronary vasodilator for angina pectoris

Front 19

Dipyridamole increases intracellular levels of cAMP by

Back 19

inhibiting cyclic nucleotide phosphodiesterase

Front 20

Dipyridamole affects thromboxane A2 how ?

Back 20

it decreases thromboxane avtivity

Front 21

Dipyridamole is effective for what?

Back 21

inhibiting embolisation from prosthetic heart valves together with warfarin

Front 22

Dipyridamole is innapropriate for

Back 22

elderly because of GI and orthostasis problems

Front 23

The function of ADP ?

Back 23

ADP acts on GPIIb/IIIa

Front 24

whats inhibts ADP acting on GPIIb/IIIa

Back 24

Ticlopidine Clopidogrel Prasugrel

Front 25

Cyclooxygenase inhibitors

Back 25

Aspirin

Front 26

Glycoprotein IIB/IIIA inhibitors

Back 26

Abciximab Eptifibatide Tirofiban

Front 27

Adenosine reuptake inhibitors

Back 27

Dipyridamole

Front 28

Phosphodiesterase inhibitor

Back 28

Cilostazol

Front 29

Cilostazol inhibits

Back 29

phosphodiesterase III
preventing cAMP degradation

Front 30

Cilostazol is a

Back 30

oral antiplatelet

Front 31

Cilostazol is contraindicated in

Back 31

congestive heart failure

Front 32

Cilostazol decreases and increases

Back 32

plasma triglycerides decreasing and HDL increased

Front 33

Extrinsic system is initiated by

Back 33

factor VII

Front 34

when is the Intrinsic system activated

Back 34

in contact with glass or highly charged surfaces by factor XII

Front 35

Prothrombin into Thrombin by

Back 35

the enzyme Xa

Front 36

role of Thrombin ?

Back 36

catalyze fibrinogen into fibrin

Front 37

Endogenous inhibitors so coagulation stays local

Back 37

proteinC proteinS antithrombin III
Tissue factor pathway inhibitor

Front 38

Drug that interferes with formation of Thrombin

Back 38

Heparin

Front 39

Heaprin is as

Back 39

Anticoagulant

Front 40

Difference btw Heparin and Enoxaparin

Back 40

Enoxaparin is a LMWH

Front 41

Heparin is used in

Back 41

Prevents Venous thrombosis
Pulmonary embolism
Acute myocardial infarction

Front 42

Heparin binds to

Back 42

antithrombin II

Front 43

Anticoagulant in pregnant women with prostethic heart valve

Back 43

Heaprin + LMWH

Front 44

LMWH advantage ?

Back 44

can be given subcutaneously and doesnt need hospitilized monitoring

Front 45

Heaprin + LMWH given intramuscular ?

Back 45

Causes hematoma

Front 46

How to treat Heparin bleeding

Back 46

Give protamine sulfate 1mg - every 100 unit heparin

Front 47

Dabigatran is a

Back 47

direct thrombin inhibitor

Front 48

Dabigatran prevents

Back 48

Stroke + Systemic Embolism

Front 49

Lepirudin is a ?

Back 49

Thrombin inhibitor

Front 50

Argatroban is a ?

Back 50

parenteral anticoagulant

Front 51

Argatroban function is to ?

Back 51

directly inhibit thrombin

Front 52

Lepirudin + Argatroban its important to

Back 52

monitor aPTT levels

Front 53

Drug to prevent deep vein thrombosis that can lead to pulmonary embolism

Back 53

Fondaparinux

Front 54

Fondaparinux can be used in

Back 54

during surgery
Hip kne replacement

Front 55

Fondaparinux can be used together with ?

Back 55

Warfarin

Front 56

Fondaparinux acts by ?

Back 56

Xa + antithrombin 3

Front 57

Vitamin K Antagonist

Back 57

Coumarin anticoagulants
such as dicumarol and warfarin

Front 58

Vit K antagonist only used in

Back 58

patients truly at risk becau morbidity

Front 59

Vitamin K is needed for ?

Back 59

protein coagulant factors

Front 60

Warfarin inhibits

Back 60

vitamin K epoxide reductase

Front 61

Warfarin is bound to in plasma?

Back 61

Albumin

Front 62

what prevents warfarin to enter CNS

Back 62

its binding to albumin

Front 63

When not to administer Warfarin

Back 63

Vit K deficiency
Hepatic disease
Pregnancy

Front 64

Thrombolytic drugs act by

Back 64

activating plasminogen to plasmin

Front 65

function of plasmin?

Back 65

hydrolyzes fibrin, dissolves clot

Front 66

Streptokinasecauses what ?

Back 66

a fibrinolytic state

Front 67

Alteplase difference to streptokinase

Back 67

acts more locally on thrombotic fibrin

Front 68

Urokinase is produced in ?

Back 68

The kidneys

Front 69

Urokinase functions is to ?

Back 69

converts plasminogen --> plasmin

Front 70

Thrombolytic drugs

Back 70

Streptokinase Urokinase

Front 71

thrombolytic drug given together with

Back 71

Aspirin or Heparin

Front 72

thrombolytic contraindicated in

Back 72

healing wound
pregnancy
braintumour
headtrauma, metastatic cancer

Front 73

Alteplase to treat

Back 73

myocardial infarction
pulmonary embolism
acute ischemic stroke

Front 74

what catalyses degradation of fibrinogen

Back 74

Streptokinase

Front 75

Streptokinase is used in

Back 75

acute pulmonary embolism
deep vein thrombosis
acute myocardial infarction

Front 76

Urokinase is produced

Back 76

by the kidneys

Front 77

Urokinase functions is ?

Back 77

directly cleaves arginine-valine bond of plasminogen to get active plasmin

Front 78

What is approved for lysis of pulmonary embolism

Back 78

Urokinase, and its only category of treatment