Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
Blood Cell Production:
What is Hemopoiesis? |
The process of blood cell production
|
|
|
Blood Cell Production:
What tissues do all blood cells come from? |
Hematopoietic stem cell
|
|
|
Blood Cell Production:
Where are blood cells produced? |
Red bone marrow
a. all types of blood cells made here b. called MYELOID HEMOPOIESIS Lymphoid Tissues a. e.g spleen,thymus,tonsils,lymph nodes b. produces lymphocytes only c. called lymphoid hemopoeisis |
|
|
Blood Cell Production:
What type of cell do all blood cells develop from? |
Hemocytoblast
a. pluripotent stem cell b. can give rise to all the blood cells c. in bone marrow |
|
|
Blood Cell Production:
What are the three hematopoietic processes? |
1. Erthropoiesis
2. leukopoiesis 3. thrombopoiesis |
|
|
Blood Cell Production:
What is Erythropoiesis and describe steps ? |
a. production of RBC's
b. 20 mL/day Hemocytoblast -> (EPO) -> Erythroblast -> loses nucleus->Reticulocyte -> leaves bone marrow & enters blood stream -> Erythrocyte -circulates in blood for ~120 days |
|
|
Blood Cell Production:
Why do Erthrocytes die? |
1. As erthrocyte ages its proteins slowly breakdown - has no further protein synthesis to renew them.
2. old erthrocytes are trapped and broken down - in spleen and liver |
|
|
Blood Cell Production:
How are dying Erthocytes disposed of? What is this process called? |
HEMOLYSIS occurs
a. releases Hb and leaves cell fragments in blood b. cell frags are digested by macrophages in liver & spleen |
|
|
Blood Cell Production:
How does Hb breakdown? |
See diagram
|
|
|
Blood Cell Production:
How is Iron metabolized after RBC death? |
1. dietary iron and recycled iron from rbc breakdown are treated the same.
2. Constantly lose Fe in feces 3. dietary iron goes thru digestive system 4. is absorbed into blood in small intestine 5. iron in blood is transported by TRANFERRIN 6. iron is transported to liver. 7. liver stores it as FERRITAN 8. iron is stored in liver and released when needed. |
|
|
Blood Cell Production:
What is leukopoiesis? |
production of WBC's
|
|
|
Blood Cell Production:
What are Colony Stimulating Factors? |
1. different CSFs for different cell lines
2. CSF's stimulate the production of cells 3. often produced by lymphocytes and macrophages in response to infection |
|
|
Blood Cell Production:
What type of cell Granulocytes originate? |
1. all come from a single stem cell called MYELOBLAST
2. mature granulocytes are stored in bone marrow until they are needed. **about 10-20 times more granulocytes in bone marrow than in circulated blood. 3. circulate for 4-8 hrs - then live in tissue and live 4-5 days |
|
|
Blood Cell Production:
Agranulocytes Where do Monocytes originate from? |
a. arise from monoblasts
b. stored in bone marrow until they are needed -**about 10-20 times more granulocytes in bone marrow than in blood c. circulated in blood for 10-20 hrs then enter tissues as macrophages -can lives as macrophages for few years. |
|
|
Blood Cell Production:
What are the two types of lymphocytes and where do they arise from? |
-B Cells
_T Cells arise from B-progenitor and T- progenitor cells production begins in bone marrow mature lymphocytes mostly live in -spleen,lymph nodes can live in body for a few weeks to a many years. |
|
|
Blood Cell Production:
What is Thrombopoiesis? |
Platelet production
mostly in bone marrow |
|
|
Blood Cell Production:
What is the Thrombopoietic process? |
Hemocytoblast ------> Megakaryoblast ---------> Megakaryocyte
|
|
|
Blood Cell Production:
What is a megakaryocyte? |
a megakaryocyte is:
1. giant cell 2. multiploid 3. mostly in bone marrow 4. pieces of cytoplasm (no nuclear material) break off and enter blood stream - these fragments are platelets |
|
|
Blood Cell Production:
Describe Platelets |
1. 25-40% of platelets are stored in spleen
2. 60-75% circulate in blood 3. live for about 4 days in blood. |
