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11 Cards in this Set

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What kind of drugs are Zidovudine (AZT), stavudine, lamivudine, lamivudine, emtricitabine, didanosine, and abacavir?
Nucleoside Reverse Transcriptase Inhibitors
What is a potential side effect of Nucleotide Reverse Transcriptase Inhibitors?
Potentially fatal syndrome of lactic acidosis with hepatic steatosis due to mitochondrial toxicity
MOA of AZT?
inhibits HIV retroviral transcriptase and causes DNA chain termination

selecticity of 100X greater that Human enzymes
What is AZT's half life? How often do you need to administer it? And does it undergo first pass hepatic metabolism?
It does undergo first pass hepatic metabolism and is excreted in the plasma with a half life of 1 hour, it needs to be administered 3 times a day
Can you use AZT as a prophalactic or with children?
It can be used as a prophalactic after sexual exposure or in the case of a needle stick, and it can be effective in the treatment of verticle transmission of HIV from mother to newborn
What are the top adverse reactions to AZT use?
Bone marrow depression, severe anemia, leucopenia thrombocytopenia, severe headache and dizziness, insomnia, NVD, malaise and myalgia (muscle pain)
What would happen if a patient on AZT was also taking a drug that inhibited glucoronidation, like cimetadine or fluconazole?
These drugs would decrease the effects of hepatic first pass effect and the AZT levels in the blood could reach toxic levels
What would happen if a patient that was on a drug that was a hepatic microenzyme inducer like rifampin (TB drug)?
the liver function would be increased and thus the AZT levels would be decreased below therapeutic levels
What is the major side effect to remember for Stavudine?
Paresthesis, Numbness and Muscle Pain
Lamivudine and Emtricitabine also effective against?
Use in the case of renal disfunction?
also effective against Hep B, Yes, not metabolized in Liver
What two AIDS drugs are ineffective alone but work in synergy together and has relatively few side effects?
Lamivudine, and Emtricitabine