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20 Cards in this Set
- Front
- Back
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XPC
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NER (induced by p53)
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DDB2
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NER (induced by p53)
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Xeroderma Pigmentosa due to?
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Defect in NER
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FasL and Fas-r
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Keratinocyte apoptosis
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Eumelanin
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black/brown
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Pheomelanin
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yellow
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MC1-R; defect?
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melanin receptor; red head! no tan
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SLC24A5
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pale skin in europeans
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POMC
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Increased by p53 in response to DNA damage
POMC activates MSH, ACTH (immunosupress), Endorphin |
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MDM2
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marks p53 for destruction
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SNP309
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INcrease MDM2, decrease p53, decrease tanning/sunburn
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Estrogen risk for Skin Ca
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SP1 Coactivator increases MDM2 affinity for SP1
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alpha-decay
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give off alpha: 2 protons, 2 neutrons
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beta-decay
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neutron to proton
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alpha radiation vs gamma radiation
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alpha: 100% ds breaks
gamma: 99% ss breaks |
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Ionization potentials
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Gamma: 1
Beta: 2 NP: 5 alpha: 20 |
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ATM
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G1/S, S, G2/M checkpoints; impt for HOMOLOGOUS RECOMB
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BRCA1 vs BRCA 2
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BRCA1: G2/M check pt for Homlogous Recomb
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Ataxia Telangiectasia due to?
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ATM Defect
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Ku70-Ku80
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Non-homologous End joining
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