Block 4 Histology Md 1 Femal Reproduction 1 Part A

Front 1

-Identify the different parts of the female reproductive system.
-Describe the major cell types and functional roles of the ovary
-Identify the developmental stages of the follicles and the hormonal factors affecting them

-Identify the roles of GnRH, FSH, estrogen, LH and progesterone in the menstrual and ovarian cycles and relate these to the morphological changes.
-Understand the morphological changes in the endometrium and myometrium during the normal menstrual cycle and during pregnancy.
-Describe micro anatomical features of External Genitalia

-Describe histological features and function of the Mammary gland
-Describe the changes in the mammary glands during pregnancy and lactation

Back 1

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Front 2

Clinical Correlates:

Contrast Uterine leiomyoma and leiomyosarcomas

Recognize clinical manifestation of endometriosis
Describe the role of human papillomavirus in cervix carcinoma
Describe the technology and use of PAP test in cervical cancer diagnosis
Describe the role of HPV infections in the etiology of Cervix cancer
Describe the role of estrogen in breast cancer

Back 2

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Front 3

female reproductive system
three structural units
on the basis of function:

Back 3

Mammary glands
Ovaries
Genital tract
...................Oviducts
...................Uterus
....................Vagina &
....................external genitalia

Front 4

The peritoneal covering of mesovarium ceases abruptly at the hilum and is replaced by a layer of =

Back 4

cuboidal
to
low columnar

germinal epithelium,
covers the free surface of the =

Hint 4

ovary

Front 5

ovary is covered by =

Back 5

germinal epithelium,

The germinal epithelium rests upon a thin =

Hint 5

basal lamina.

Front 6

ovary is attached to thin

Back 6

broad ligament by a double fold of peritoneum, the =.

Hint 6

mesovarium

Front 7

of

Back 7

peritoneum aka =

Hint 7

mesovarium

Front 8

mesovarium describe =

Back 8

broad ligament
a double fold

broad ligament aka =

Hint 8

peritoneum

Front 9

suspensory ligament, which contains the

Back 9

ovarian vasculature
nerves,

is directed upward over the iliac vessels.

Hint 9

upward over the iliac vessels.

Front 10

suspensory ligament
is directed upward over the

Back 10

iliac vessels.

P

Hint 10

Front 11

Beneath the epithelium there is a layer of _____ _____ the tunica albuginea, which increases in _______ with advancing ___.

Back 11

CT

density

age

Front 12

Ovary

thick outer layer, the cortex

smaller inner portion, the medulla

There is no =

Back 12

distinct line of demarcation between the two zones.

Medulla: consists of =

Hint 12

-loose fibroelastic CT
large blood vessels,
lymphatics
nerves.

-scattered smooth muscle fibers.

Front 13

Ovary

Cortex made up of =

Back 13

reticular fibers
, fibroblast like stromal cells
arranged in
‘swirly’ pattern

Front 14

Ovary Cortex

Scattered in this stroma, there are ovarian follicles at various stages of development. =

Back 14

-Before puberty =
-Sexual maturity is characterized by the presence of growing =
-After menopause, follicle =

Hint 14

-only primordial follicles are seen.

-growing follicles and their products

-follicle disappear
cortex eventually becomes a narrow zone of
fibrous CT

Front 15

During early fetal development, primordial germ cells called =

Back 15

oogonia

Front 16

primordial germ cells called oogonia migrate from =

Back 16

embryonic yolk sac

Front 17

By the __ & __ months of fetal development in the human, some oogonia enlarge and assume the potential for development into mature gametes.

Back 17

4th & 5th

Front 18

At 4/5th month stage ______ become known as ____ ____ and commence the first stage of _____ division.

Back 18

oogonia

primary oocyte

meiotic

Front 19

By the __ month of fetal development, the primary oocytes become encapsulated by a single layer of flattened follicular cells, of epithelial origin, to form ________ _______ =

Back 19

7th

primordial follicles.

Front 20

By the seventh month of fetal development, the primary oocytes become encapsulated by a single layer of flattened ______ cells, of ________ origin, to form primordial follicles.

Back 20

follicular

epithelial

Front 21

Follicular cells produce oocytes ____ _____ to prevent the earlier completion of _____ _____ of the of the primary oocyte

Back 21

maturation inhibitor

meiotic prophase

Front 22

slide 10

Back 22

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