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Slide 34
Development of the Atrial Septum
Formation: composed of =
septum primum
septum secundum
foramen primum
foramen secundum
The crescent-shaped ______ _____ forms in the roof of the primitive atrium and grows toward the atrioventricular (AV) cushions in the AV canal.
septum primum
The foramen secundum forms in the center of the =
septum primum

The crescent-shaped septum secundum forms to the
right of the septum primum.
The______ -______ is the opening between the upper and lower limbs of the _______ ______
foramen ovale

septum secundum.
Before birth the foramen ovale allows blood to pass from the
right atrium into the left atrium


Reflux of blood is prevented by the valve
After birth the foramen ovale normally closes by fusion of the ____ ______ and the ______ _______
septum primum

septum secundum.
DEVELOPMENT OF RIGHT ATRIUM

Develops from:
right horn of the sinus venosus
primitive atrium.
right horn of the sinus venosus
& the
primitive atrium Develops the =
RIGHT ATRIUM
DEVELOPMENT OF RIGHT ATRIUM

sinus venosus develops a left horn which becomes the ____ _____ and a right horn which will be incorporated into the_____ ______
coronary sinus

right atrium.
_____ _____ develops a left horn which becomes the coronary sinus and a ____ ____ which will be incorporated into the right atrium.
sinus venosus

right horn
DEVELOPMENT OF RIGHT  ATRIUM

The smooth part of the right atrium, the sinus venarum, is derived from the =
DEVELOPMENT OF RIGHT ATRIUM

The smooth part of the right atrium, the sinus venarum, is derived from the =
sinus venosus

whereas the muscular part, the auricle, is derived from the =
sinus venosus

whereas the muscular part, the auricle, is derived from the =
primitive atrium.
primitive atrium.
DEVELOPMENT OF RIGHT ATRIUM

The smooth part of the right atrium, the____ _______ , is derived from the sinus venosus whereas the____ _____ of the auricle, is derived from the primitive atrium.
sinus venarum

muscular part,

The 2 portions are separated internally by the =
and externally by the =
crista terminalis

sulcus terminalis.
DEVELOPMENT OF LEFT ATRIUM

Development of the left atrium occurs concurrently with that of the
right atrium.

L atrium develops from:
2ct
pulmonary veins
Primordial atrium
DEVELOPMENT OF LEFT ATRIUM
pulmonary veins
Primordial atrium
develope what =
L atrium develops from:
DEVELOPMENT OF LEFT ATRIUM
L atrium develops from:
2ct
pulmonary veins
Primordial atrium
DEVELOPMENT OF LEFT ATRIUM

During the early part of the _____ week an outgrowth of the pulmonary veins appear from the left atrium.
4th wk

As the atrium expands, the primordial pulmonary vein and its main branches are gradually incorporated into the wall of the____ ____
left atrium.
As a result 4 pulmonary veins are formed. Molecular studies have confirmed that atrial myoblasts migrate into the walls of the pulmonary veins.

The small left auricle is derived from the primordial atrium. Its internal surface has a rough trabeculated appearance
.During ___ week an outgrowth of the pulmonary veins appear
4th
4th
The Interventricular (IV) Septum

Formation: has 3 parts:
muscular part
membranous part
IV foramen
The Interventricular (IV) Septum

***The muscular ___ _____
develops in the midline on the floor of the primitive ventricle and grows toward the fused AV cushions.
IV septum
IV foramen

This foramen is closed by the membranous IV septum, which forms by the proliferation and fusion of tissue from three sources: the
***right bulbar ridge,
***left bulbar ridge,
AV cushions.
Formation of the Aorticopulmonary (AP) Septum

Neural crest cells migrate from the =
hindbrain region
through
pharyngeal arches 3, 4, 6

and invade both the truncal ridges and bulbar ridges.
The_______ & ____ ridges grow and twist around each other in a _____ fashion and eventually fuse to form the
_____ ___________
truncal and bulbar

spiral

AP septum.
Formation of the Aorticopulmonary (AP) Septum

The AP septum divides the___________ __________ into the aorta and pulmonary trunk.
truncus arteriosus and bulbus cordis
truncus arteriosus and bulbus cordis
Formation of the Aorticopulmonary (AP) Septum

The AP septum divides the truncus arteriosus and bulbus cordis into the ________ _________
aorta and pulmonary trunk.