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13 Cards in this Set
- Front
- Back
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Distinct episodes of neourologic deficits, separated in time, attributable to white matter lesions that are separated in space?
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MS
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What is the progression of MS?
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steady chronic and progressive
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WHat is the haplotype associated with MS?
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DR2
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What is the pathogenesis of MS?
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cellular immune response generated against componenets of the myelin sheath
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What can be said of the plaque borders of MS?
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sharply defined
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Bedises the lateral ventricles, what other areas of WM are susceptible to MS?
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optic nerves
chiasm asc and desc fiber tracts of brain stem, cerebellum and cord |
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What will the CSF look like in a patient with MS?
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Mild protein elevation
moderate pleocytosis increased gamma globulin |
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What will cause an increase in gamma globulin in the CSF of an MS patient?
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prolifeation of B cells in the nervous system
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What is a sign of increased gamma globulin in MS?
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oligoclnal bands
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What is a demyelinating disease that is usually present in asians and exhibits bilateral optic neuritis with prominant SC involvement?
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Neuromyelitis optica (Devic Disease)
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What is the form of MS that presents in young individuals, has afulminant course and has widespread myelin destruction with some axonal loss?
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Marburg Form
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Is the gray matter involved in Devic Disease?
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yes
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Which demyelinating disease involves rapidly evolving quadriplegia and can occur in the setting of alcoholism, orthotopic liver transplant, and possibly upon rapid correction of sever hyponatremia?
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Central Pontine Myelinolysis
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