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17 Cards in this Set
- Front
- Back
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Azoles
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Inhibit 14-alpha-demethylase
Deplete ergosterol Accumulate toxic sterols Damage Cytoplasmic Membrane |
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Allylamines
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Inhibit squalene oxidase
Deplete ergosterol Accumulate toxic sterols Damage Cytoplasmic Membrane |
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Amphoteracin B
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Binds ergosterol in fungal cell membrane
Causes leak |
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Echinocandins
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Non-Competetive Inhibition of 1,3-B D-glucan Synthesis
Cell wall becomes permeable |
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Macrolides
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Bind 50s Subunit
(-) Transpeptidation (-) Translocation |
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Ketolide
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Bind Domain II and V of Ribosome 50s Subunit
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Clindamycin
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Identical MOA to Macrolide
Bind 50s Subunit (-) Transpeptidation (-) Translocation |
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Linezolids
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Inhibits initiation complex of 50s Ribosome Subunit
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Streptogramin
Synercid |
Inhibit peptidyl transferase on 50s Ribosome subunit
(sequential) |
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Tetracyclines
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Prevents binding of tRNA to mRNA on 30s Ribosome Subunit
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Glycyclines
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Identical to Tetracycline(Prevents binding of tRNA to mRNA on 30s Ribosome Subunit) but large Substituent at position 9 blocks resistance mechanisms.
Efflux Pumps Ribosomal Modification |
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Chloramphenicol
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Binds 50s Subunit
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Aminoglycoside
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Inhibits 30s Ribosome Subunit
Misread => add wrong AA Blocks translocation => AA release before completion |
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Fluroquinolones
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Inhibit Topoisomerase II (gyrase) and IV
DNA stays cleaved no coiling |
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Antifolates/Sulfonamides
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Bind Dihydrofolic Acid Reductase
Mimic PABA Reduces available nucleotides |
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Isoniazid (INH)
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Competetive inhibition of Mycolate Synthetase
No Mycolic Acid for cell wall |
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Rifampin
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Inhibits DNA-dependent RNA polymerase
St |
