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18 Cards in this Set
- Front
- Back
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3 main properties that retard clot formation in UNinjured vessels
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Lamellar flow
Negative charge on endothelial cells and platelets (repulsion) Endothelial cells shield pro-aggregatory components |
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What layer of the blood vessel wall is rich in pro-aggregatory components?
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SUB-endothelial layer
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What does PGI-2 do?
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Prevents platelet aggregation
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What does thromobmodulin do?
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Binds thrombin and activates protein C
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What does heparan sulfate do?
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Catalyzes anti-thrombin inactivation of coagulation enzymes
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Where is tPA released from?
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Endothelium
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How does Tissue Factor Pathway Inhibitor work?
(mechanism) |
TFPI binds Factor Xa
TFPI/Xa binds to TF/FVII A QUATERNARY complex is formed, blocking extrinsic pathway |
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How is TFPI overcome (3)?
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TFPI deficiency
Faulty TPFI binding to FXa Massive expression of tissue factor (this happens in vascular injury) |
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What is Factor V Leiden?
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An abnormal "version" of Factor V that is resistant to Protein C
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What clotting factors does Protein C degrade (2)?
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Factors V, and VIII
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What is Protein S?
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A "co-factor" that, along w/ Protein C, attacks FV and FVIII
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What are the 3 main ANTI-coagulant pathways
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TFPI pathway
Protein C pathway Anti-thrombin pathway |
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What coag factors does anti-thrombin affect?
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Factors II, IX, XI, X
Also, Protein C |
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How many saccharide units of heparin are needed to activate anti-thrombin?
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A minimum of 18
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What is released after plasmin breaks down fibrin?
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D-dimer
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What does alpha-2 plasmin inhibitor do?
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Binds and clears free plasmin
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What does plasminogen activator inhibitor (PAI) do?
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Binds and clears tPA
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3 factors in Virchow's triad
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Damage to VESSEL WALL
Change in FLOW BLOOD coagulability state |
