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6 Cards in this Set
- Front
- Back
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functions of serotonin
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modulates normal GI function
initiates peristaltic and secretory reflexes, intestinal wall motility activate IPAN (intrinsic primary afferent neurons) to secrete ACh, also affect wall contractions - sensory for digestive tube environment (wall distention, lumen chemistry) |
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function of enterochromaffin (EC) cells and 5-HT
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secrete 5-HT (serotonin) > binds to 5-HT receptors
eliminated by SERT (reuptake transporters) on enterocytes or liver metabolism |
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ethanol metabolism
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EtOH > [alchohol dehydrogenase] > acetaldehyde > [aldehyde dehydrogenase] > acetic acid
consumes NADH to make NAD+ > can block gluconeogenesis > causes ketoacidosis acetaldehyde is toxic product |
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microsomal ethanol oxidase system
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CYP2E1 enzyme plays small role in EtOH metabolism, but in high dose, can compete against drug metabolism
chronic dose > upregulate CYP2E1 > clearance of drugs is faster |
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purine metabolism
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all tissues can degrade purines, only liver/small intestine with xanthine oxidase can make urate
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gout mechanism
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synoviocytes (fibroblasts) line joint cavities and phagocytose urate crystals > secrete inflammatory cytokines > attract immune cells
treatment: colchicine/glucocorticoid (antiinflammatory), NSAID (COX inhibition) |
