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40 Cards in this Set
- Front
- Back
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MOA of NSAID's
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Inhibition of COX isoenzymes is the MOA of what drugs?
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COX-1 catalyzes the synthesis of ____ and ____ in the stomach.
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PGE2 and PGI2 synthesis is catalyzed by what enzyme?
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Coticosteroids MOA
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Inhibition of Phospholipase A2 and COX-2 is the MOA for ____.
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Prostaglandin Analogs
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Alprostadil
Misoprostol Epoprostenol |
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A prostaglandin analog used in the treatment of erectile dysfunction
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Alprostadil is a ____ used in the treatment of ____.
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A prostaglandin analog used in the prevention of peptic ulcers.
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Misoprostol is a ____ used to prevent ____.
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Epoprostenol is a _____ used in the treatment of ____.
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A prostoglandin analog used in the treatment of severe pulmonary hypertension.
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Histamine is stored in vesicles of ____ and ____.
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Mast cells and basophils store high concentrations of what?
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What are the enzymes that break down histamine?
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Monoamine oxidase and diamine oxidase metabolize what?
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Blocking histamines is an important method of treating what conditions?
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GERD and peptic ulcer are often treated with what?
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What is the major metabolite of histamine metabolism?
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Imidazoleacetic acid is what?
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What does histamine do?
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Bronchoconstriction
Vasodilation Increased Capillary Permeability Stimulation of Sensory Nerve Endings Increased Gastric Secretion |
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What substances may cause unexpected anaphylactoid reactions?
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Tubocurarine
Succinylcholine Morphine Radio-contrast Media Carbohydrate Plasma Expanders |
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Drug of choice for anaphalaxis?
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Epinephrine is the drug of choice for what condition?
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Symptoms of anaphylaxis?
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Hypotension
Vasodilation Myocardial Depression Dysrhythmia Urticaria Angioedema Bronchospasm |
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The Triple Response
1- Red injection site from local vasodilation 2- Flare caused by axon reflex 3- Wheal (lump) is edema from increased capillary permeability What's the cause? |
Intradermal administration of histamine causes what response?
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Motion Sickness is treated with what first-generation H1 Antagonists?
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Cyclizine and Meclizine are used to treat what condition?
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Hydroxyzine is widely used as a treatment for what condition?
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Skin allergies are often treated with what First-Generation H1 Antagonist?
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Diphenhydramine
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H1 Antagonist
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Dimenhydrinate
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H1 Antagonist
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Clemastine
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H1 Antagonist
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Carbinoxamine
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H1 Antagonist
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Promethazine
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H1 Antagonist
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Azelastine
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H1 Antagonist
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List all the H1 Antagonists
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Diphenhydramine
Dimenhydramine Clemastine Carbinoxamine Promethazine Azelastine |
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What is Azelastine used as and what is it metabolized to?
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A nasal spray and opthalmic agent metabolized to desmethylazelastine (active metabolite).
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Second Generation H1 Antagonists have what benefits?
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Less lipid soluble
Free of sedation Can use for chronic cases Metabolized by liver in 12-24 hrs. |
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Name all the Second Generation H1 Antagonists
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Fexofenadine
Loratadine Cetrizine |
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Fexofenadine
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Second Generation H1 Antagonist
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Loratadine
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Second Generation H1 Antagonist
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Cetrizine
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Second Generation H1 Antagonist
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Side Effects of H1 Antagonists
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Antimuscarinic- Dry mouth/blurred vision
Alpha Blocking- Orthostatic Hypotension |
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Azole Antifungal Agents can cause lethal arrhythmias by what mechanism?
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Ihibition of CYP-450 system causes high levels of antihistamines can result in what condition? What substance can cause this?
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Name the H2 receptor blocking agents
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Cimetidine
Ranitidine Famotidine Nizatidine |
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Cimetidine
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H2 receptor blocking agent
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Ranitidine
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H2 receptor blocking agent
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Famotidine
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H2 receptor blocking agent
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Nizatidine
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H2 receptor blocking agent
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Clinical Uses of H2 Antagonists
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*** Duodenal Ulcer ***
Gastric Ulcer Zollinger Ellison Syndrome GERD Reflux esophagitis |
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Proton Pump Inhibitors are more effective than H2 blockers in the treatment of what condition?
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Zollinger Ellison Syndrome (acid hypersecretion) is treated with what medications?
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