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40 Cards in this Set

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  • Back
MOA of NSAID's
Inhibition of COX isoenzymes is the MOA of what drugs?
COX-1 catalyzes the synthesis of ____ and ____ in the stomach.
PGE2 and PGI2 synthesis is catalyzed by what enzyme?
Coticosteroids MOA
Inhibition of Phospholipase A2 and COX-2 is the MOA for ____.
Prostaglandin Analogs
Alprostadil
Misoprostol
Epoprostenol
A prostaglandin analog used in the treatment of erectile dysfunction
Alprostadil is a ____ used in the treatment of ____.
A prostaglandin analog used in the prevention of peptic ulcers.
Misoprostol is a ____ used to prevent ____.
Epoprostenol is a _____ used in the treatment of ____.
A prostoglandin analog used in the treatment of severe pulmonary hypertension.
Histamine is stored in vesicles of ____ and ____.
Mast cells and basophils store high concentrations of what?
What are the enzymes that break down histamine?
Monoamine oxidase and diamine oxidase metabolize what?
Blocking histamines is an important method of treating what conditions?
GERD and peptic ulcer are often treated with what?
What is the major metabolite of histamine metabolism?
Imidazoleacetic acid is what?
What does histamine do?
Bronchoconstriction
Vasodilation
Increased Capillary Permeability
Stimulation of Sensory Nerve Endings
Increased Gastric Secretion
What substances may cause unexpected anaphylactoid reactions?
Tubocurarine
Succinylcholine
Morphine
Radio-contrast Media
Carbohydrate Plasma Expanders
Drug of choice for anaphalaxis?
Epinephrine is the drug of choice for what condition?
Symptoms of anaphylaxis?
Hypotension
Vasodilation
Myocardial Depression
Dysrhythmia
Urticaria
Angioedema
Bronchospasm
The Triple Response

1- Red injection site from local vasodilation
2- Flare caused by axon reflex
3- Wheal (lump) is edema from increased capillary permeability

What's the cause?
Intradermal administration of histamine causes what response?
Motion Sickness is treated with what first-generation H1 Antagonists?
Cyclizine and Meclizine are used to treat what condition?
Hydroxyzine is widely used as a treatment for what condition?
Skin allergies are often treated with what First-Generation H1 Antagonist?
Diphenhydramine
H1 Antagonist
Dimenhydrinate
H1 Antagonist
Clemastine
H1 Antagonist
Carbinoxamine
H1 Antagonist
Promethazine
H1 Antagonist
Azelastine
H1 Antagonist
List all the H1 Antagonists
Diphenhydramine
Dimenhydramine
Clemastine
Carbinoxamine
Promethazine
Azelastine
What is Azelastine used as and what is it metabolized to?
A nasal spray and opthalmic agent metabolized to desmethylazelastine (active metabolite).
Second Generation H1 Antagonists have what benefits?
Less lipid soluble
Free of sedation
Can use for chronic cases
Metabolized by liver in 12-24 hrs.
Name all the Second Generation H1 Antagonists
Fexofenadine
Loratadine
Cetrizine
Fexofenadine
Second Generation H1 Antagonist
Loratadine
Second Generation H1 Antagonist
Cetrizine
Second Generation H1 Antagonist
Side Effects of H1 Antagonists
Antimuscarinic- Dry mouth/blurred vision

Alpha Blocking- Orthostatic Hypotension
Azole Antifungal Agents can cause lethal arrhythmias by what mechanism?
Ihibition of CYP-450 system causes high levels of antihistamines can result in what condition? What substance can cause this?
Name the H2 receptor blocking agents
Cimetidine
Ranitidine
Famotidine
Nizatidine
Cimetidine
H2 receptor blocking agent
Ranitidine
H2 receptor blocking agent
Famotidine
H2 receptor blocking agent
Nizatidine
H2 receptor blocking agent
Clinical Uses of H2 Antagonists
*** Duodenal Ulcer ***
Gastric Ulcer
Zollinger Ellison Syndrome
GERD
Reflux esophagitis
Proton Pump Inhibitors are more effective than H2 blockers in the treatment of what condition?
Zollinger Ellison Syndrome (acid hypersecretion) is treated with what medications?