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10 Cards in this Set
- Front
- Back
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Insulin binds insulin receptor
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Binds alpha subunits of tetrameric insulin receptor; activates tyrosine kinase->autophosphorylation; phosphorylates IRS; 2ry messenger pathways activated (PI3K/PKB and SOS/RAS/RAF) to alter protein synthesis and existing proteins; more intracellular GLUT4 vesicles fuse on cell membrane to transport glucose into cell
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Glucagon receptor
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GPCR that activates adenylate cyclase and results in cAMP accumulation -> Ca2+ mobilization -> PKA -> increased blood glucose
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Ras
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a
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JAK/STAT
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a
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AKT
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a
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BCR/ABL
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a
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Rb
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Gatekeeper TSG that modulates cell-cycle progression b/w G1/S by binding E2F to stop transcription of S-phase genes. When hyperphosphorylated by cyclin/CDK complex, it releases E2F to begin transcription.
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p53
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a
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BRCA1/2
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BRCA1 and 2 are caretaker TSGs that repair double stranded breaks, control cell cycle checkpoint responses and chromosomal segregation.
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HER2/neu
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Receptors in the EGFR family that are tyrosine kinases that activate PI3K (anti-apoptosis) and Ras (proliferation).
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