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16 Cards in this Set
- Front
- Back
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deficiency of alpha2 antiplasm causes a hypercoag or bleeding state
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bleeding state
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deficiency of plasminogen activator inhibitor causes a hypercoag or bleeding state
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bleeding state
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too much of plasminogen activator inhibitor causes a hypercoag or bleeding state
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hypercoag
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too much of alpha2 antiplasm causes a hypercoag or bleeding state
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hypercoag
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model of coagulation
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initiation - due to exposed TF -> activation of factor X -> activation of a small amount of thrombin -> 5,8,11 activation
amplification - thrombin generation from platelet propagation - more factor 10 yeilds more thrombin |
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thromboelastography
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measure clot elasticity
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platelet function analyzer
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ex vivo measure of adhesion and aggreation in collagen coated cartridge
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a patient with a normal PTT but abnormal PT likely has a deficiency in what
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factor VII
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neonatal alloimmune thrombocytopenia (NAIT) pathogenesis
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platelets almost zero
due to polymorphism in alpha-IIb/beta-III - get a Rh-like alloimmunization during pregnancy common antigens PI-A1 (HPA-1), Brb (HPA-5), Pen (HPA-4) |
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neonatal alloimmune thrombocytopenia (NAIT) treatment
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IVIg, corticosteroids
watch for next pregnancy |
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hemophilia pathogenesis
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hemophilia A is more common - deficiency in factor VIII
hemophilia B - deficiency in factor IX hemophilia C - deficiency in factor XI see hemorrhage - large volume bleeds bleed into joints - enlarged joints |
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hemophilia treatment
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DDAVP - for factor VIII only - causes tissue to release factor VIII
FVIII or FIX recombinant therapy |
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what is the most common inherited bleeding disorder? clotting disorder?
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bleeding disorder - von Willebrand disease
clotting disorder - factor V leiden |
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von willebrand disease types
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type 1 - not enough vWF
type 2A - vWF dysfunction get abnornal binding type 2M - multimers are too big - hidners aggregation type 2B - overactive vWF binds everywhere including platelet to platelet binding -> thrombocytopenia type 3 - no vWF at all |
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why do people with von Willebrand disease have mild hemophilia?
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vWF carries factor 8
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von willebrand disease treatment
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DDVAP to get more release of vWF
restore deficient factor |
