Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
A deficiency in either HEME or GLOBIN chain synthesis resulting in decreased Hg production results in what type of anemia?
|
Hypochromic Microcytic Anemia
|
|
|
Iron deficiency and Thalassemia are associated with what anemia?
|
Hypochromic Microcytic Anemia
|
|
|
Kiolonychia and Pica can be seen with what?
|
Hypochromic Microcytic Anemia
|
|
|
What is Ferritin?
|
Primary storage form of Iron, readily released
found in BM, spleen, and liver |
|
|
What is hemosiderin?
|
Long term storage of iron, slow release
water insoluble and stains with Prussian blue |
|
|
What is the carrier protein of iron?
|
Transferrin
|
|
|
In Iron Deficent Anemia, is it hypo or normochromic and what is the RDW like?
|
Hypochromic
Increased RDW |
|
|
Total iron binding capacity is Increased of Decreased in iron deficiency anemia?
*** |
INCREASED
|
|
|
what is TIBC?
|
the Fe concentration necessary to saturate the iron-binding sites of transferrin
|
|
|
what is Total iron binding capacity like in (Anemia of Chronic disease) ACD?
|
Decreased
|
|
|
what is decreased in all stages of iron deficiency and is often the first indicator of iron deficiency?
|
Serum Ferritin
note: if there is some kind of infection or immune process it will be falsely elevated |
|
|
What is a good screening test to find Thalassemia? what will the levels be like?
** |
Free Erythrocyte Protoporphyrin or Zinc Protoporphyrin
in every form EXCEPT Thalassemia, it will be increased in Thalassemia, the levels will be normal |
|
|
SUMMARY FOR IRON DEFICIENCY:
Serum ferritin quantitation: ? Serum Iron: ? TIBC: ? %Saturation: ? Free erythrocyte protoporphyrin: ? Zinc protoporphyrin: ? increase or decreased |
Serum ferritin quantitation (decreased)
Serum Iron: (decreased) TIBC: (Increased) %Saturation: (decreased) Free erythrocyte protoporphyrin (increased) Zinc protoporphyrin (increased) |
|
|
What is Sideroblastic anemia?
|
Either a block in the incorporation of iron into the protoporphyrin ring to form heme
|
|
|
What is a defect in iron reutilization?
|
Anemia of chronic disease
aka abnormal iron metabolism |
|
|
In sideroblastic anemia, what will be 2 characteristic findings?
|
Increase in total body iron
Presence of ringed sideroblasts (eryhtrocell has large chunky iron forming in rings around it) |
|
|
Acquired Sideroblastic Anemia is normally due to what 2 things?
*** |
Alcohol and Lead
|
|
|
What causes Anemia of Chronic Disease? what mediates this? how?
|
Results from a normal physiologic immune response to protect the host from microorganisms and/or tumor cells
Cytokines release results in iron deprivation to proliferating cells (organisms/tumor cells) |
|
|
what type of cytokines cause anemia of chronic disease? how?
|
Inhibitory cytokines (TNF-B, IL-1/6, INF-gamma, hepcidin) adversely impact erythropoiesis
Cytokines effect disturbances in iron homeostasis Shunting of iron into macrophages compounded by decreased macrophage release of iron (impaired iron recycling) Inhibition of erythroid progenitor cell proliferation and differentiation Decreased erythrocyte survival time |
|
|
Rheumatoid arthritis
Systemic lupus Inflammatory bowel disease Sarcoidosis can be associated with what? |
Anemia of Chronic Disease Disease Associations
|
|
|
What will TIBC be like in Anemia of Chronic Disease Disease ?
** |
Decreased
|
|
|
What will TIBC be like in Anemia of Chronic Disease Disease ?
** |
Decreased
|
|
|
Where is iron absorbed?
|
duodenum
|
|
|
How does iron anemia initially present?
|
Initially, N/N anemia followed by classic Hypochromic, Microcytic Anemia
|
|
|
What is the HALLMARK of ACD?
|
Increased Ferritin
|
