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9 Cards in this Set
- Front
- Back
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Provide in order a list of the investigations you will order for a patient whom you expect to have a hematologic malignancy:
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1. CBC and peripheral smear: to ID cytopenia and presence of blasts.
2. Bone Marrow Aspirate and biopsy: are diagnostic, malignant blasts fill the marrow space replacing normal hematopoietic cells. |
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How would you confirm your diagnosis of acute leukemia?
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Bone Marrow aspiration.
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A 61-year-old man is diagnosed with Non-Hodgkin Lymphoma which requires staging. In addition to a complete blood count (CBC) and a CT scan of his chest and abdomen to evaluate lymphadenopathy, what other diagnostic procedures are necessary to stage this patient's lymphoma?
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Bone marrow aspirate and biopsy; and CT scan of chest and abdomen
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What is the diagnostic laboratory finding in Chronic Myeloid Leukemia:
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Philadelphia chromosome
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Once you have a diagnosis of an acute leukemia what will your next step be?
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To differentiate between AML and ALL.
-Flow cytometry -Genetic tests to ID specific mutations |
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Name a histological morphological feature which is pathogonomic of AML.
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Auer rod )abnormal cytoplasmic granules which look like red needles)
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You are a pediatrics resident covering the oncology service at the regional Children`s Hospital. You admit a boy with acute leukemia, and the diagnostic tests are all performed at your hospital. Once the diagnosis of "acute leukemia" is established, the next most important piece of information you require from the lab is; how would you do this?
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To determine if there is myeloid or lymphoid differentiation in the leukemic blasts?
-Flow cytometry -Genetic tests to ID specific mutations |
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A patient presents with asymptomatic cervical lymphatenopathy, they have a rubbery consistency. The patient’s sister said she looked pale. You suspect lymphoma, what investigations would you order, please be able to justify your answer.
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CBC; cytopenia
Liver function tests: R/o liver involvement CXR, CT chest: lymph node involvement Lymph node biopsy: confirm diagnosis |
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If the girl with lymphatenopathy also presented with B symptoms, weight loss, fever, and night sweats what further tests would you order?
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Bone marrow biopsy to access marrow infiltration of lyuphoma.
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