B&l Final Study Set

Front 1

What chronic myleoproliferative disorders have the Jack2 mutation?

Back 1

Polcythemia rubra vera
essential thrombocytosis
myelofibrosis

Front 2

What chronic myleoproliferative disorder does not have the Jack2 mutation?

Back 2

CML

Front 3

Monoclonal gamopathies involve what cell type?

Back 3

plasma cells

Front 4

What Ig type is most prevalant in muliple myeloma?

Back 4

IgG>IgA

Front 5

What are the diagnostic criteria for multiple myeloma?

Back 5

plasmacytoma
>30% plasma cells in bone marrow
>3.5 g/dl IgG or >2.0 g/dl IgA

Front 6

What are the side effects of vinblastine?

Back 6

Bone marrow depression

Front 7

What drugs are mitotic inhibitors? Are these drugs CCS or CCNS?

Back 7

Vinca Alkaloids (vincristine, vinblastine)
Taxans - Paclitaxel

CCS- M phase

Hint 7

Vin and Cristi blasted my Pacific Taxes mitotically

Front 8

What drugs are topoisomerase inhibitors?

Back 8

Etoposide (a podophyllotoixin)
Topotechan, Irinotecan (camptothecins)

Hint 8

E is topside, camping at the Top o the tecans.
Ir is in O tecan's

Front 9

What is the method of action of the vinca alkaloids?

Back 9

Spindle poison, binds tubulin and inhibits mitotic division. CCS-M phase

Front 10

How are vinca alkyloids administered? Where are they metabolized?

Back 10

I.V. only
Liver

Front 11

What are the C.U's of vinblastine?

Back 11

Hodgkin's and metastatic testicular cancers.

Hint 11

Vin and hodge blast testicular cancers!

Front 12

What are the c.u.'s of vincristine? and in what regimines?

Back 12

Hodgkins' (mopp)
Non-Hodgkin's (chop)

Hint 12

Zack hodge mopps the floor.

Front 13

What are the side effects of vincristine?

Back 13

Neurotoxicity, P.N. paresthesis

Hint 13

cristi is PARAnoid of NEURO PaiN.

Front 14

What is the MOA of taxanes?

Back 14

bind tubulin and decrease depolymerization. Stabalize microtubules decreases mitosis.

Hint 14

taxes prevent the country from braking down.

Front 15

What are the clinical uses of taxanes?

Back 15

I.V. infusion of solid tumors. Including metastatic ovarian cancer, breast, bladder, lung, head neck, and prostate

Front 16

What is the fist line therapy for breast cancer?

Back 16

Paclitaxel + trastuzumab + bevacizumab

Hint 16

pac your trastes and beverage were going to zumab.

Front 17

What is the therapy for Ovarian Cancer?

Back 17

Paclitaxel + Cisplatin

Hint 17

Ovaries pac platinum.

Front 18

What are the side effects of Paclitaxel?

Back 18

dose limiting myelosupression, myalgia, alopecia, **sever allergic rxs**

Hint 18

MY AL and MYELO are ALLERGIC to ALOPECIA

Front 19

What is the pre treatment for paclitaxel?

Back 19

Dexamethasone and diphenhydramine

Front 20

What are the advantages of Abraxane?

Back 20

Albumin bound taxane. No allergic rxs and less myelotoxic

Front 21

What is the method of action of Etoposide?

Back 21

Binds to Topoisomerase II. Inhibits late S-G2 phase.

Front 22

What are the clinical uses of etoposide and what drug is it used with?

Back 22

Broad spectrum used with cisplatin.

Hint 22

There is platinum on the topside

Front 23

What are the side effects of etoposide?

Back 23

Myelosupression alopecia mild NV

Hint 23

Myelo was supressed on the topside of NV because there he got alopecia.

Front 24

What is the method of action of camptothecins?

Back 24

Inhibits topoisomerase I

Hint 24

you only go camping ir (near) the top of the tecans once

Front 25

What are the clinical uses of Topotecan?

Back 25

small cell lung cancer and metestatic ovarian cancer.

Hint 25

Hiking to the top of the tecans hurts my lungs so bad it feels like my ovaries metastasized to my small lungs

Front 26

What is the C.U. for Irinotecan

Back 26

Colorectal cancer with 5-FU

Hint 26

Interesting RINO's have 5- FLOURescnet COLONS

Front 27

What are the side effects of Camptothecins?

Back 27

mycositis, myelosupression, moderate N.V. diarrhea (esp irinotecan)

Hint 27

camping in NV mylo got diarrhea and said my cost is...

Front 28

What Antibiotics are discussed the the cancer 2 lecture?

Back 28

Dactinomycin, Doxorubicin, Daunorubicin, Bleomycin

Hint 28

DoxDauno rubicin, DactBleo mycin

Front 29

What is the MOA of anti-cancer antibiotics?

Back 29

Intercalates in the DNA CCNS drugs

Front 30

What is the MOA of Dactinomycin?

Back 30

Intercalates between adjacent guanine and cytosine residues. Prevents unwinding of DNA and DNA dependent RNA synth

Hint 30

D sounds kinda like G wich always pairs with C and prevents unwinding of the Dna

Front 31

Are antibiotic anti-cancers CCS or CCNS?

Back 31

CCNS

Front 32

What are the CU's of Dactinomycin?

Back 32

Wilms tumor in children + vincristine, rhabdomyosarcoma, methotrexate resistant coriocarcinoma.

Front 33

What are the side effects of Dactinomycin?

Back 33

Dose limiting Myelosupression, Dermatitis & Acne, Sever NV erythema.

Hint 33

Dact M.D has acne and blushes (eyethema) like he's going to vomit!

Front 34

What are the Anthracycline antibiotics?

Back 34

Daunorubicin Doxorubicin

Front 35

What is the MOA of Anthracycline's?

Back 35

Intercalate's DNA, Inhibits Topoisomerase II
** increases O2 free radicals**
Anthracycline drugs are Daunorubicin and Doxorubicin

Hint 35

Daun and Dox are always the top 2 radicals.
Anthrax cycles between daun and docs (x)

Front 36

What is the CU of daunorubicin?

Back 36

acute myelogenous and lymphocytic leukemias. Often given with cytarabine.

Front 37

What is the CU of doxorubicin?

Back 37

broad spectrum. solid tumor cancer of the breast, ovary testes endometrium, thyroid lung.

Front 38

What is a treatment protocol for Breast Cancer?

Back 38

Doxorubicin + Paclitaxel

Front 39

What are the SE of doxorubicin?

Back 39

Severe alopecia, Red urin, Mucocitis, myelosuppression.
**Cardiomyopathy** CHF arrhythmia's 50% mortality

Hint 39

Cardiologist Doc(x) rubicin lost his wig and peed red when myelo shot him with mucus.

Front 40

What can be used to decrease cardiomyopathy with doxorubicin use?

Back 40

dexrazoxane which chelates Fe and decreases O2 free radicals

Hint 40

doc rubicin prevents radical (O2 radicals)shaving accidents by using the DEXterity RAZOR(doxrazoxane)

Front 41

What is the MOA of Bleomycin?

Back 41

Binds DNA and induces scission by increasing O2 radicals.

Hint 41

BleOmycin (binds, DNA, Increases O2)

Front 42

What are the SE of Bleomycin?

Back 42

Pneumonitis and Pulmonary Fibrosis- dose related.

Hint 42

Bleo (leo) pulls (pneumonitis) on the fibers (fibrosis)

Front 43

What is the use and MOA of Amifostine? What drug is is commonly used with?

Back 43

Converted to a free thiol, acts as a scavenger of superoxide ions. Used to reduce nephrotoxicity of Cisplatin.

Hint 43

Treat kids with fosting and platinum candy.

Front 44

What is the MOA of Mesna and what is it used for?

Back 44

Prophylactic agent used to decrease cyclophosphamide induced hemorrhagic cystitis

Front 45

What is Dexrazoxane used for?

Back 45

A cardioprotective agent used with dexorubicin.
Chelating agent that interferes with iron-mediated free radical formation with is thought to be the cause of anthracycline induced cardiomyopothy.

Front 46

What is an example of an adrenocorticosterioid?

Back 46

Prednisone

Front 47

What are two antiestrogens?

Back 47

Tamoxifen, Fulvestrant

Front 48

What is an example of an antiandrogen

Back 48

Flutamide

Front 49

What are two Gonadotropin-releasing hormone agonists?

Back 49

Goserelin, Leuprolide acetate

Hint 49

Gonadotropin reLeAsing

Front 50

What is the rational for using adrenocorticosterioids (prednisone)?

Back 50

Steroid interferes with mitosis, have a lymphocytic effect and causes regression of the lymphatic tissue.
IMMUNOSUPRESSINVE

Front 51

What is the clinical use of prednisone?

Back 51

Combination therapy with cytotoxic agents for treatment of Hodgkin's, and non-hodgkin's lymphomas, leukemias, and myelomas and breast cancers

Front 52

What are the side effects of prednisone?

Back 52

Generally well tolerated and can produce feeling of euforia, mild appetite stimulator. Long term use- Cushing's Habitus, Na retention, edema, peptic ulcer, increased infection.

Hint 52

EPI is a cushy habit that is N.A. to me.

Front 53

What is Dexrazoxane used for?

Back 53

A cardioprotective agent used with dexorubicin.
Chelating agent that interferes with iron-mediated free radical formation with is thought to be the cause of anthracycline induced cardiomyopothy.

Front 54

What is an example of an adrenocorticosterioid?

Back 54

Prednisone

Front 55

What are two antiestrogens?

Back 55

Tamoxifen, Fulvestrant

Front 56

What is an example of an antiandrogen

Back 56

Flutamide

Front 57

What are two Gonadotropin-releasing hormone agonists?

Back 57

Goserelin, Leuprolide acetate

Hint 57

Gonadotropin reLeAsing