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16 Cards in this Set
- Front
- Back
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Influence the survival, proliferation and differentiation of hematopoietic stem and progenitor cells
Act only in the local environment what does this describe? |
cytokines
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what is the general composition of blood?
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45% consists of cells (1.6% luekocytes, even less is platelets)
the rest is plasma (93% water, rest is proteins) |
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job of G6PD?
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takes free radicals from oxidized state and reduces them, produces water and prevents harm
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what does 2,3, BPG do?
not on test haha |
modulates the affinity of the Hg for O2 (facilitates the release of 02 to the tissues)
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What is the single most abundant intracellular protein.
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Hemoglobin
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What are the 3 types of adult Hg? What is the major one?
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A (97%) Alpha2/Beta2
A2 (2%) Alpha2/Delta2 F (1%) Alpha2/Gamma2 |
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What are the two forms of eryhtrocytosis and their causes?
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Relative:
--No increase in red cell mass, but a decrease in plasma volume. Dehydration (diruetics, ethanol, excessive perspiration) Absolute: --Actual increase in RBC mass --seen in high altitude, or PULMONARY DISEASE, renal disease, and neoplastic conditions |
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Any condition resulting from a significant decrease in total body red cell mass=
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Anemia
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with respect to anemia..
mass= ? |
remember anemia is Any condition resulting from a significant decrease in total body red cell mass
so mass= production x survival which is to say mass will be changed by things that increase/decrease production, and things that decrease survival |
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What are 3 physciological changes seen with anemia?
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Tachy cardia
Vasoconstriction/shunting Decreased O2 affinity to Hg (Increased production of 2-3 DPG shifting the oxygen dissociation curve to the right) |
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note: ANEMIA IS NOT A DISEASE
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it is a SYMPTOM of a disease
OLD AGE IS NOT A NORMAL CAUSE OF ANEMIA!! |
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What 5 things do the CBC give you?
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ERYTHROCYTE COUNT
HEMATOCRIT HEMOGLOBIN CONCENTRATION RBC INDICES PERIPHERAL SMEAR REVIEW |
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A Coulter counter does what? what if the value is high
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Gives you your Erythrocyte count
Counts cells in a fixed and known volume note: White cells are also included (so if the number is high, you must suspect that the person has elevated WBCs) |
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What is hematocrit?
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Total vol. of red cells relative to total vol. of whole blood in a sample.
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Describe the number of red cells in a human when they are at their highest level and lowest.
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Highest at birth, lowest at 2 months, then increasing to adult values at puberty
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Hb, RBC, Hematocrit are all dependent on what?
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age and sex
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