B&l: 19. Fischler : Langerhans Cell Histiocytosis, Spleen, And Thymus

Front 1

What marker is used to identify Langerhans Cell Histiocytosis?

**TEST QUESTION

Back 1

S-100

Front 2

Characterized by proliferation of a special type of immature dendritic cell, cells contain cytoplasmic Birbeck granules. By EM, Birbeck granules are pentalaminar, tubular, and often have a dilated terminal end (has a tennis racket appearance)

what is this seen in?

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Back 2

Langerhans Cell Histiocytosis

Front 3

usually occurs before two years of age; may affect adults
characterized by cutaneous lesions over trunk and scalp
associated with lymphadenopathy, hepatosplenomegaly, pulmonary lesions, and osteolytic bone lesions
marrow infiltration

what does this describe? What does this fall under?

Back 3

Letterer-Siwe Disease

falls under Langerhans Cell Histiocytosis

Front 4

Hand-Schuller-Christian triad-->
Combination of calvarial bone defects, exopthalmos, and diabetes insipidus

can be seen in?

Back 4

Langerhans Cell Histiocytosis

Front 5

16 year old girl, with strong smoking history dies. On day of death she is complaining of vomiting, SOB. Xray shows that both lungs had collapsed. The lungs were S-100 positive, what did the pt die of?

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Back 5

Langerhans Cell Histiocytosis

Front 6

What is the main cause of congestive splenomegaly?

Back 6

Cirrhosis of the liver-

Front 7

What 2 cells are predominantly found in the Thymus

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Back 7

thymic epithelial cells & immature lymphocytes (T-cell lineage)

Front 8

Thymic Hyperplasia is seen in 75% of what cases?

Back 8

myasthenia gravis