B&l: 18. Fischler : Myelodysplastic Syndromes And Chronic Myeloproliferative Disorders

Front 1

A group of clonal stem cell disorders characterized by maturation defects associated with ineffective hematopoiesis and high risk of transformation to acute myeloid leukemia =

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Back 1

Myelodysplastic Syndrome

Front 2

peripheral blood cytopenias (low counts of white, red, etc) should make you think?

**TEST QUESTION

Back 2

Myelodysplastic Syndrome

Front 3

Middle aged female with peripheral blood with thrombocytosis (<5% blasts) and bone marrow with increased hypolobated megakaryotes is known as what? What does this fall under?

**TEST

Back 3

5q- Syndrome

this is a type of Myelodysplastic Syndrome

Front 4

there is a disordered or dysplastic differentiation affecting erythroid, granulocytic, monocytic, and megakaryocytic lineages found in....

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Back 4

Myelodysplastic Syndromes (MDS)

Front 5

Have increased production of one or more terminally differentiated myeloid elements usually resulting in elevated peripheral blood counts=

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Back 5

Myeloproliferative Disorders

Front 6

What is the common feature found in Myeloproliferative Disorders?

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Back 6

Mutate tyrosine Kinases

Front 7

Chronic Myeloid Leukemia is diagnosed with what genetic marker?

**TEST QUESTION

Back 7

BCR-ABL fusion gene (Philadelphia chromosome [Ph])

Front 8

increased marrow production of red cells, granulocytes, and platelets (panmyelosis)
the increase in red cells causes most of the clinical symptoms=

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Back 8

Polycythemia Vera

note: increased red cells = polycythemia

Front 9

What is the genetics underlying Polycythemia Vera?

**TEST QUESTION

Back 9

tyrosine kinase mutation: JAK2 point mutations ( > 95% frequency)

Front 10

Increased proliferation and production of the megakaryocytic elements
Patients commonly with platelet counts over 600,000 per mm3
Is a diagnosis of exclusion; features of other chronic myeloproliferative disorders are absent=?

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Back 10

Essential Thrombocytosis

Front 11

Erythromelalgia involving the hands (burning feeling of the hands) is associated with?

Back 11

Essential Thrombocytosis

Front 12

Characterized by the development of obliterative marrow fibrosis; there is suppression of bone marrow hematopoiesis, resulting in peripheral blood cytopenias and extensive neoplastic extramedullary hematopoiesis in the liver, spleen and lymph nodes = ?

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Back 12

Primary Myelofibrosis