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13 Cards in this Set
- Front
- Back
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What is the difference in hematopoietic activity in the bone marrow between an adult and an infant? **
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At birth, all of the marrow is hematopoietically active
In the adult, only half of the marrow is active |
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Examination of the bone marrow includes looking at the cellular content. What is the cellular content in an adult? What if the cellular content is increased? Decreased? **
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50% cellularity in a 50 year old (ration of cells to fat is 1:1)
Increase in cellular content is termed HYPERPLASTIC Decrease in cellular content is termed HYPOPLASTIC |
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What is the favored site of bone marrow aspiration? **
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Iliac crest
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Bone marrow aspiration is super painful, so why do we even bother doing it? **
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We evaluate BM because it matures/transfers very quickly, so it is very indicative of what is happening in the body at that time
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What are the potential causes of erroneous INCREASES in WBC with automated counters? **
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Unlysed red cells, nucleated red cells
platelet clumping monoclonal proteins, cryofibrinogen, cryoglobulin heparin |
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What are the potential causes of erroneous DECREASES in WBC with automated counters? **
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smudge cells
clotting uremia with immunosuppressants |
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Leukocyte counts vary based on physiologic states, one of which is exercise. Explain this. **
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When we draw blood, we put the needle into the central axle stream of the vein. Only 50% of the cells are actually freely floating, while the other 50% are attached to the cell wall (marginating pool). With exercise, you have a shift of leukocytes into the central axle stream (due to mechanics), leading to a perceived leukocytosis.
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What is neutropenia? What is the number one cause? **
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A reduction in the number of neutrophils in the blood.
Number one cause is DRUG TOXICITY |
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The important cause of eosinophilia?
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Neoplastic disorders (Hodgkins lymphoma is the important one to remember here)
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The important cause of basophilia?
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Myeloproliferative disease
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Where do B and T cells reside in the lymph node?
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B cells are in the follicles (germinal centers)
T cells are in the parafolicular space |
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How would you expect the nodes to present in Acute Lymphadenitis?
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tender, enlarged, prominent reactive germinal centers
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What are the three types of Chronic Lymphadenitis?
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Follicular hyperplasia- B cells!
Paracortical lymphoid hyperplasia- T cells! Sinus histiocytosis- medulla! |
