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4 Cards in this Set
- Front
- Back
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Lithium
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Drug for bipolar disorder
-acute therapy -drug of choice for euphoric mania- acts w/in 5-7 days -short half life-- 2x/day |
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Lithium ADRs
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Therapeutic levels:
-GI (N,V,D)-transient -Tremors (fine: hand)- beta blockers -thirst (polydipsia) + frequent urination (polyuria) -muscle weakness -lethargy, confusion, memory impairment, HA Higher Levels: -worsening of above -irritability, incoordination, seizures -ECG changes, hypotension -Renal toxicity (nephrotoxin) Less dose dependent -goiter and hypothyroidism -teratogenesis, possibly |
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Valproic acid (VPA) in bipolar
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Mood-stabilizing AED
-equally effective as lithium and usually preferred due to faster onset, fewer ADRs and easier to use -alters GABA mediated transmission A/E: -GI common -Hepatotoxicity, pancreatitis, thrombocytopenia (decrease platelets) all rare |
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Carbamazepine (in bipolar)
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Mood-stabilizing AEDs
-alternative drug: often favored to lithium (except for euphoric mania) due to fewer ADRs -less experience than VPA -mech not known A/E: -CNS (HA, ataxia) initially but tolerance develops -Hematologic rare -induces CYP 450 enzymes |
