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30 Cards in this Set
- Front
- Back
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What is Avastin (Bevacuzimab) used for?
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various cancers
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What is Epogen or procrit used for?
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anemia
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What is embrel used for?
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RA
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What is herceptin (trastuzumab) used for?
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breast cancer
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What is humira used for?
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RA or PA
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What is Lantus used for?
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diabetes
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What is neulasta used for?
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neutropenia
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What is novolog used for?
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diabetes
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What is remicade (infliximab) used for?
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inflammatory disorders
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What is rituximab or rituxan used for?
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RA, or non-hodskins lymphoma
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What is pulmozyme / dornase alpha and what does it do?
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Pulmozyme is a DNase 1. It is an enzyme endonuclease that digests extracellular DNA in cystic fibrosis patients to reduce mucus viscosity in the lungs
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What are used for acute mycardial infarction and other clinical applications?
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Thrombolytic agents / thrombolytic therapy
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What enzyme activates plasminogen to become plasmin and lead to the fibrinolysis of fibrin clot?
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Tissue plasminogen activator or t-PA
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Is t-PA naturally occuring?
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yes
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What is Alteplase?
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recombinant t-PA (glycosylated CHO) - advantage of being clot specific, disadvantage of inconvenient administration
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What is reteplase?
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second generation recombinant thobolutic agent. Made in ecoli. Nonglycosylated.
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What are factor VIII, plasma protein, and cofactor in blood coagulation? What are they used to treat?
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recombinant coagulation factors. Used to treat hemophilia A - factor VIII therapy linked to Ryan White
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Why did the national hemophilia foundation ask to remove all albumin from rh factor VIII?
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due to the potential to carry disease causing viruses or prions
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What is derived from aspergillus niger (second gen biotech) and is used for the breakdown of sugars from certain foods?
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alpha-galactosidase / beano
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Who first came out with HGH?
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Genentech in 1977 with somatotropin. later somatrem or Protropin
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What are possible adverse side effects in peds to HGH?
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benign intracranial hypertension, glucose intolerance, anti-hgh antibodies
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What are possible adverse side effects in adults?
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increase bodyweight, swollen joints
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What are the metabolic disorders HGH can be used for?
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aids wasting or short bowel syndrome
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Who recieved the Noble prize for insulin and when?
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Banting and Macleod in 1923
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WHat is the number of different amino acids between human insulin and bovine? porcine?
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3 aas between human and bovine, 1 between human and porcine
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What year was first rh Insulin made and by who?
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1978 by genentech in ecoli licensed to Eli Lilly: humulin
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What year did the FDA approve Humalog?
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1996
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How many recombinant insulins and analogs by 2005?
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20
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What is FSH?
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Follicle stimulating hormone. Used to increase the number of oocytes available for assisted reproductive technologies or to treat anovulation
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What grows FSH?
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CHO
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