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26 Cards in this Set

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  • 3rd side (hint)
Name the 4 interferon alpha

and give their common structural feature
2a (Roferon®-A)
2b (Intron® A)
n1 (Wellferon®)
n3 (Alferon® N)

Recombinant human Interferon Alpha
FDA-approved indications of
Interferon alpha
2a (Roferon®-A)
2b (Intron® A)
n1 (Wellferon®)
n3 (Alferon® N)
FDA-approved indications

Hairy cell leukemia
AIDS-related Kaposi's sarcoma
chronic myelogenous leukemia (CML)
Chronic hepatitis B and C
genital warts
papillomavirus
What are remarkable features of

Interferon alpha
2a (Roferon®-A)

HINT: MAJOR ADVERSE REACTIONS
2b (Intron® A)
n1 (Wellferon®)
n3 (Alferon® N)
Major adverse reactions are fever,
myalgia
headache;
i.e., flu-like symptoms.
Name:

a. an interferon alfacon-1

b. its structural feature

c. FDA approved indications
a. Infergen®

b. Consensus alpha interferon

c. Chronic Hepatitis C
Remarkable fact of Interferon alfacon-1,Infergen®?

HINT: ONE OF ITS KIND
The first second generation interferon
Name:

a. the 2 Peginterferon alfa

b. their structural feature

c. FDA approved indication
a. 2a (Pegasys)
2b (PEG-INTRON)

b. Pegylated recombinant human interferon alpha

c. FDA approved indications:
Chronic hepatitis C alone or with ribavirin
Remarkable feature of Peginterferon alfa:
2a (Pegasys)
2b (PEG-INTRON)

HINT: Benefits of pegylation
Pegylation allows once/week dosing
Name the 3 interferons that treat Chronic hepatitis C
Interferon alfacon-1
(Infergen)

Peginterferon alfa
2a (Pegasys)
2b (PEG-INTRON)
Name:

a. the 4 interferon beta drugs

b. their structural feature

c. FDA approved indication
a.1b (Betaseron®, Extavia®)
1a (Avonex®, Rebif®)

b. recombinant human interferon beta

c. Tx of relapsing, remitting MS and 2ndary MS
Remarkable feature interferon beta drugs
1b (Betaseron®, Extavia®)
1a (Avonex®, Rebif®)
HINT: 1. DOSAGE FORM
2. ADVERSE REACTIONS
Form: single-use, pre-filled syringes
Adverse reactions: flu-like symptoms
Name:
a. the 1 interferon gamma-1-b drug:

b. its structural feature

c. FDA approved indication
a. Actimmune

b. recombinant human interferon gamma

c. Reduces frequency/severity of infections associated with chronic granulomatous disease;
delays disease progression in severe, malignant osteopetrosis
Remarkable features of Interferon gamma-1-b, Actimmune?HINT: Administration
Administered SQ three times weekly at 50 μg/m2
Name:
a. a recombinant human interleukin-2 drug

b. its FDA approved indication
a. Aldesleukin (Proleukin)

b. metastatic malignant melanoma
metastatic renal cell carcinoma
Remarkable features of Aldesleukin (Proleukin)?
HINT: SEVERE ADVERSE REACTIONS
Severe toxicity (capillary leak syndrome)
Cardiac arrythmias
Myocardial Infarction
respiratory failure
GI bleeding
Kidney failure

Name:

a. thrombopoeitic growth factor, IL-11

b. its FDA approved indications
a. Oprelvekin (Neumega)

b. Prevention of chemotherapy-associated thrombocytopenia
Remarkable features of Oprevelkin (Neumega)?
HINT: ADMINISTRATION & DOSING
Administer SQ 50mcg/kg every day for adults for 14-21 days
Name:

a. a selective interleukin 1- receptor antagonist

b. its FDA approved indications
a. Anakinra (Kineret)

b. Rheumatoid arthritis alone or with other DMARDs
Remarkable features of Anakinra (Kineret), a selective interleukin 1-receptor antagonist?

HINT: ADMINISTRATION & DOSING
Administer SQ 100 mg/day
monitor neutrophil count for 3 months
Name:

a. a granulocyte colony stimulating factor

b. its FDA approved indication
a. Filgrastim (Neupogen)

b. Neutropenia in:
chemotherapy
bone marrow transplant
other neutropenias
Remarkable features of Filgastrim (Neupogen)?

HINT: EFFECTIVENESS
Reduces
bacterial infection mortality,
incidence
duration of hospitalization.
Name:

a. the modified Filgrastim

b. its FDA approved indication
a. Pegfilgrastim (Neulasta)

b. Decrease chemotherapy-associated neutropenia
a. What would you use for myeloid reconstitution after chemotherapy and to promote bone marrow transplant?

Pegflgrastim (Neulasta)

Sargramostin (Leukine/Prokine)

Filgrastim (Neupogen)

Romiplostim (Nplate)

b. State the drug's structural feature
a. Sargramostim (Leukine/Prokine)

b. granulocyte-macrophage colony stimulating factor
Remarkable feature of Sargramostin (Leukine/Prokine)?

HINT: DOSING CONSIDERATIONS
Half dose if:
neutrophil count <20,000 cells/cc
& platelets <500,000/cc
a. What would you use to treat chronic immune (idiopathic) thrombocytpenic purpura?

b. State why. (Structural feature of drug)
a. Rominoplostim (Nplate)

b. thrombopoetin mimetic
Remarkable features of Rominoplostim (Nplate)?
A peptibody consisting of IgG1 Fc fused to a peptide with 2 TPO receptor-binding domains
a. If you were an endurance athlete and wanted outdo your oponents during your next race, what drug would you try to get on the street market?

b. State why (Structural feature)
a. Epoeitin alfa (Epogen)
First US biotechnology blockbuster drug

b. cytokine that stimulates production of red blood cells.