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193 Cards in this Set

  • Front
  • Back

what types of nervous systems do sea anemone have and what are the major functions

nerve net





what types of nervous systems do flatworms have and what are their major functions

eyespots, paired ganglia, ventral nerve cord

what types of nervous systems do earthworms have and what are their major functions

brain, ventral nerve cord, segmental ganglion

what types of nervous systems do insects have and what are their major functions

brain, eye, ventral nerve cord

what types of nervous systems do squid have and what are their major functions

eye, brain, giant axon

what types of nervous system do frogs have and what are their major functions

eye, brain, dorsal spinal cord, nerves

do all organisms have nervous systems?

yes except for sponges

what types of nervous systems do humans have and what are their major functions

CNS/PNS


sensory neurons-receive and transmit information about an animals environment or internal physiological state


interneurons-process and transmit info. to different regions


motor neurons-create appropriate response (movement) or adjust internal physiological state


circuits-formed by interconnected neurons

what is cephalization

concentration of nervous system components at 1 end of the body





what advantages does cephalization have

is an adaptation for forward locomotion and adaptation for predation

what are the major parts of a neuron

cell body (soma)


dendrites


axon


axon hillock


synapses


postsynaptic cell


axon terminal

what does the cell body do

contains the nucleus

what do the dendrites do

highly branched processes where signals from axons of other cells are received

what does the axon do

conducts electrical impulses away from the cell body

what does the axon hillock do

last site in the soma where membrane potentials are summated before being transmitted to the axon.

what do synapses do

small gap separating neurons

what does the postsynaptic cell do

place for neurotransmitter molecules to bind

what does the axon terminal do

transmit a neurotransmitter from one neuron to another

what are the major types of glial cells

astrocytes


schwann cells


oligodendrocytes

what is the function of an astrocyte

contribute to blood brain barrier (nutrition, development)

what is the function of a schwann cell

works in the PNS

what is the function of an oligodendrocyte

works in the CNS

How do thenumbers of glial cells compare to the number ofneurons

glial cells are much more numerous than neurons in the human cortex but they're even everywhere else

what is the function of glial cells

provide nutrition and physical support to neurons

Why is the voltage of neurons negative inside relative to theoutside

because neurons create membrane potentials in order to allow specific ions to pass through

how is the resting potential maintained

Potassium ions can cross through the membrane, while chloride and sodium ions have more problems crossing.




the inside is more negatively charged than the outside

When we say that K has an equilibrium potential of -85 mV,what does that mean

it means that at -85mV, the entire action potential is in equilibrium.




so, when K is at -85, NA is at +68 mV

is the concentration of K higher inside or outside of the cell

inside

is the concentration of Na higher inside or outside of the cell

outside (na)

is the concentration of Cl higher inside or outside of the cell

outside (Cl)

is the concentration of Ca higher inside or outside of the cell

higher on the inside compared to NA

What types of channels are located in the dendrites, soma,axon hillock, axon, Node of Ranvier, internode, axon terminal?

voltage-gated ion channels

what is threshold

when the inward current carried by Na exceeds the outward current through K channels, creating positive feedback

What events take place in each phase of an action potential

depolarization-voltage gated na+ channels open, voltage heads towards E[na]




repolarization-na channels inactivate (and close) and K channels open more slowly




hyperpolarization-open K channels start closing and NA channels start to de-inactivate

what channels are open when

depolarization- Na+ channels open




repolarization- K channels opening slowly




hyper polarization- all channels closed

what is the refractory period and why is there one

period before another AP can happen




when neurons cannot fire another action potential, Na channels are inactivated and K channels are slowly closing

how do action potentials propagate down axons

Na+ enters the axon


charge spreads away from the sodium channels causing sections of nearby membrane to depolarize


depolarization causes Na+ channels downstream to open, and positive feedback occurs

What determines the speed of an action potential

depends on the diameter of the axon

What roledoes myelin play

layers of myelin insulate the axon and as a result, action potentials "jump" from node to node, increasing the speed of conduction

what is saltatory conduction

when AP jump from node to node

What are the steps in synaptic transmission at the synapse

-begins with action potential conduction to the axon terminal


-depolarization of the axon terminal opens voltage gated CA2+ channels


-vesicles respond by fusing with the presynaptic membrane, releasing neurotransmitters


-neurotransmitters bind with receptors on post synaptic cleft


-after inactivation, neurotransmitters are reabsorbed into the presynaptic terminal and stored in vesicles until the next AP arrives

what is the role of calcium

triggers the fusion of a synaptic vesicle with the pre synaptic membrane

What are the major neurotransmitters in the nervous system

glutamate-primary excitatory neurotransmitters in CNS (learning/memory)


GABA-primary inhibitory transmitter int eh CNS (spinal cord)


Acetylcholine-excitatory at neuromuscular junctions, but inhibitory in other areas (heart)


Monoamines- often modulatory and act via 2nd messengers, can be excitatory or inhibitory (G-proteins)

What is an EPSP

excitatory post synaptic potentials- usually cause the membrane to depolarize, bringing the cell toward the threshold

what is an IPSP

inhibitory post synaptic potential-usually cause the membrane to hyper polarize bringing the cell away from the threshold

what are spatial and temporal summation

temporal- multiple EPSP's arrive quickly at a single synapse and set off an action potential




spatial- single EPSP's at two or more different synapses set off an action potential

what part of the nervous system is the CNS

brain and spinal cord

what part of the nervous system is the PNS

cranial and spinal nerves

what is the difference between afferent and efferent

Afferent=TOWARDS Cns




efferent=AWAY from cns

what is the difference between the somatic and autonomic

somatic=voluntary




autonomic=involuntary

what is the sympathetic nervous system

-fight/flight; arousal increased activity


-sympathetic ganglia in the middle of the spinal cord


-monitor and regulate internal functions of the body

what is the parasympathetic nervous system

-rest/digest


-cranial nerves/nerves from the lower section of the spinal cord


-also monitor and regulate internal functions of the body

what is a reflex and how does it work

-stretch receptor sends signal along sensory nerves


-sensory neuron synapses with a motor neuron in spinal cord


-motor neuron sends excitatory signal to same extensor muscle which contracts

How is sensory input transduced so that the nervoussystem can understand it

the conversion of an external stimulus into an electrical signal by a sensory receptor cell

what are some types of sensory receptors

chemoreceptors-perceive specific molecules or classes of molecules


mechanoreceptors-respond to touch or pressure


thermoreceptors-dtect temperature changes


nocireceptors-sense pain or harmful stimuli


photoreceptors-respond to wavelengths of light in the visible spectrum


electroreceptors-detect electrical fields

What must transduction do to be effective

must convey the strength of the signal


carry info. about even weak stimuli when necessary


convey the location of a signals source


filter out unimportant background signals

what is lateral inhibition

inhibition that neighboring neurons in brain pathways have on each other

when does adaptation occur

adaptation to continuous stimuli reduces the firing rate over time

how does smell work

receptors are coupled to G-proteins which activate cAMP to open a channel permeable to Na+, Ca2+, depolarizing the sensory neuron

why is the sense of smell in humans so poor

bc half of these genes that express olfactory receptor proteins are mutated, making them nonfunctional

How can we detect so many differentodors

bc each neuron only has 1 type of receptor, and each receptor protein binds a small set of molecules

what are the basic tastes

sour


sweet


bitter


salty


savory (umami)

how are different tastes transduced

saltiness= Na+ in food entering Na+ channels


sourness=protons lower the pH the more sour a food tastes


sweetness/bitterness=harder to pin down

why do many different foods taste bitter

triggered by the binding of molecules to G protein-coupled receptors on the cell membranes of taste buds

how do hair cells transduce signals

-pressure wave bends stereo cilia


-potassium channels open


-membrane depolarizes


-calcium flows in


-synaptic vesicles fuse


-neurotransmitter is released

how do hair cells detect gravity and motion

-hair cells sense water vibrations which may mean a predator/prey is near


-the statolith moves and depresses hair cell stereocilia providing gravity detection

what is sound frequency

the number of pressure waves per second

what is pitch

differences in the sound frequency

How does the nervous system distinguish betweenloud and quiet sounds

the amplitude of the waves determines loudness by producing larger vibrations that cause sterocilia to bend more

How is the duration of a sound signaled

by the basilar membrane and hair cell activation

what are the major parts of the human ear

outer ear


middle ear


inner ear

what is the function of the outer ear

collects pressure waves in air and funnels them into the ear canal

what is the function of the middle ear

ear ossicles (malleus, incus, stapes) vibrate against one another and amplify sound

what is the function of the inner ear

responsible for balancing


vestibular and auditory nerves

How does the nervous system distinguishdifferent sound frequencies

sounds of different frequencies cause the basilar membrane to vibrate in specific spots along its length, resulting in the bending of hair cell steriocilia at these spots

what is the eye cup

light hits photoreceprots

what is the compound eye

good at detecting motion



what is the single lens eye

focuses light on a retina and allows for a high degree of acuity (SQUID)

how do photoreceptors detect light

retinal changes shape when it absorbs a photon of light, leading to a change in the opsin's conformation

what are the major parts of the eye

sclera


cornea


iris


pupil

what is the function of the sclera

tough, white outermost layer

what is the function of the cornea

transparent sheet of connective tissue; front part of the sclera, front of the eye

what is the function of the iris

a colored, round muscle just behind the cornea. iris can contract or explained to control the amount of light entering the eye through the pupil

what is the function of the pupil

the hole in the center of the iris

how are rods and cones different in what they detect

rods=sensitive to dim light, but not to color


cones=much less sensitive to faint light, but are stimulated by different wavelengths of light (colors)

how do we detect color

brain distinguishes color by integrating information from the 3 types of ospins

do animals detect color the same way we do

how well an animal can see color depends on the number of cones and the particular spins it has

why do we have a blind spot

due to the axons of retinal ganglion cells that project to the brain via the optic nerve

what are the major parts of the brain

forebrain


midbrain


hindbrain

function of the forebrain

cerebral cortex, thalamus, hypothalamus

function of the midbrain

brain stem

function of the hindbrain

pons and medulla, cerebellum

what are the lobes of the cerebrum

temporal


frontal


occipital


parietal

function of the temporal lobe

auditory perception, memory, speech

function of the parietal lobe

movement, orientation, recognition, perceptuon

function of the frontal lobe

reasoning, planning, speech, movement, emotions, problem solivng

function of the occipital lobe

visual processing

How have lesion studies, imaging studies and stimulationduring surgery been used to map brain areas? what has been found?

studies of people with brain damage, fMRI studies to map brain areas, electrical stimulation during brain surgery




electrical stimulation of portions of the brain caused patients to report sensations of movement, temperature, touch

What part of the brain is critical for forming long-termmemories

hippocampus

How does long-term potentiation work

-discovered in the hippocampus


-best model for how learning and memory work


-found at synapses where glutamate is the neurotransmitter


-results in an increase in the strength or weight of the synapse

what are the different types of muscle

skeletal


cardiac


smooth

what is the structure of the skeletal muscle

striated


connect bones


multinucleate


long


unbranched


voluntary

what is a sarcomere

a section between 2 discs; shorten when the muscle contracts and lengthen when the muscle is stretched

what makes up a sarcomere

myosin and actin

how does the sliding filament model explain muscle contraction

actin (THIN) filaments of muscle fibers slide past the myosin (THICK) filaments during muscle contraction while the 2 groups of filaments remain at relatively constant rates

how do actin and myosin interact during contraction? explain the cross bridge theory

-myosin head binds ATP leading to detachment from actin


-myosin head catalyzes the hydrolysis of ATP, forming ADP and Pi-> cocking the myosin head back


-myosin head binds actin, forming a cross bridge

what role does ATP play

ate must be present for myosin to relate from actin

How do action potentials lead to muscle contraction

an action potential from a motor neuron arrives at the terminal leading to release of acetylcholine which diffuses across the cleft to bind to receptors on the motor neuron, opening channels causing a depolarization of of 10s of mV leading to an action potential in the muscle

what are t-tubules

intersect with the sarcoplasmic reticulum and the depolarization there causes the release of calcium

what role does the sarcoplasmic reticulum play

the sarcoplasmic reticulum regulates the release and intake of calcium into the muscle

what is the role of calcium in muscle contraction

calcium binds to troponin which causes movement of tropomyosin exposing myosin binding sites on actin and resulting in the formation of cross bridges to produce contraction

what role do troponin and tropomyosin play in muscle contraction

they help regulate muscle contraction


troponin binds to actin and tropomyosin binds to troponin

how does a muscle relax

calcium is pumped back into the sarcoplasmic reticulum which then breaks the bonds between actin and myosin. actin and myosin return to their original state causing relaxation to occur

What happens if ACh receptors are blocked or ifcalcium pumps in the SR are blocked?

if calcium pumps are blocked, the muscle will never be able to relax




if ACh receptors are blocked, the muscle will never be able to contract

how is smooth muscle contraction different

-smooth muscle lacks the troponin-tropomyosin mechanism for regulating contraction


-smooth muscle activated by the autonomic nervous system, muscle stretch, hormones or other factors. with activation:


1. calcium enters via voltage and stretch receptor calcium channels and calcium is released from the SR


2. myosin kinase phosphorylates the myosin heads


3. the phosphorylated myosin heads bind actin and begin the cross-bridge cycle


4. a phosphate dephosphorylates the myosin heads, myosin unbinds and the muscle relaxes

What determines the sarcomere length that givesthe maximum contraction

1. changes in overlap between myosin and actin affect the number of cross-bridges and thus the force


2. maximal force at an intermediate sarcomere length (~2.3 micrometers)



how are muscle force and shortening velocity related

INVERSELY RELATED


maximum isometric force occurs at intermediate sarcomere lengths where the greatest number of cross-bridges can form




when a muscle is actively lengthened, it generates increased force (lengthening contraction)

what is a lengthening contraction

when a muscle is actively lengthened, it generates increased force

Why do we need antagonistic pairs of muscles, suchas extensors and flexors

muscles generate force only by pulling on the skeleton, so muscles are arranged in antagonist pairs




-triceps shorten to extend


-biceps shorten to flex

what is a twitch

a contraction with a delay in force

what is a tetanus

muscle force sums to higher levels when action potentials stimulate the muscle at higher rates, reaching a tetanus

what is a motor unit

a motor neuron and the population of muscle fibers (cells) it activates

what is a slow twitch muscle

-red muscle


-many mitochondria


-well supplied with blood vessels


-use aerobic respiration


-maximum tension is low, develops more slowly, but is highly resistant to fatigue


-long distance runners, swimmers, cyclists



what is a fast twitch muscle

-white muscle


-few mitochondria


-little myoglobin


-rely on anaerobic glycolysis


-has high atpase activity


-develop maximum tension rapidly with great tension, but fatigue easily


-cannot replenish ATP fast enough to sustain contractions


-weight lifters, sprinters

what are the 3 types of skeletons

hydrostatic skeletons


exoskeletons


endoskeletons

what is an exoskeleton

hard hollow structures that envelope the body


hardened outer structure to which muscles attach internally, provides protection and helps prevent dehydration. hard to repair and requires molting for growth

what is an endoskeleton

hard structures inside the body composed of connective tissues (cartilage and bone)



what are tendons

connects muscle to bone

what are ligaments

connects bone to bone

what is bone

made by osteoblasts, cells that secrete calcium phosphate with small amounts of calcium carbonate and collagen fibers to form a hard extracellular matrix

what is cartilage

made up of cells scattered in a gelatinous matrix of polysaccharides and protein fibers. provides padding between bones

how are bones formed

1. axial skeletons (Skull and ribs) precursor cells differentiate into osteoblasts which immediately produce bone (slow process)


2. most other bones are formed as cartilage first (endochondrial ossification)

what are osteoclasts

remove bone from the inside

what are osteoblasts

deposit new bone on the outside

what are the major types of joints

ball and socket


hinge



what range of motion do ball and socket joints provide

shoulder/hip


broader range of motion (3D)


allow motion along all 3 axes

what range of motion do hinge joints provide

elbow, knee


primarily flexion and extensions


limit motion to 1 primary axis

how do bones grow

as cartilage is further transformed into bone, new cartilage continues to be added at the growth plate, causing the bone to grow in length

how are bones repaired

repair of damaged endoskeleton can be done by osteoblasts and osteoclasts

why do we need to breathe

to sustain cellular respiration


-O2 is needed to burn carbs, lipids, and proteins to make ATP

what is Fick's law

O2 and CO2 can diffuse in the greatest amounts when


a) the surface area for gas exchange is large


b) the respiratory surface is extremely thin


c) the partial pressure gradient of the gas across the surface is large

How can we compute the partial pressure of oxygenat sea level

atmospheric pressure at sea level is 760 mmHg




-the sum of the partial pressures of a mixture of gases equals the total atmospheric pressure

how does partial pressure change with altitude

as altitude increases, partial pressure decreases

How does the proportion of oxygen in air changewith altitude

the percentage of oxygen in the air stays the same




higher altitudes does deliver less oxygen/breath

how do gills work

they are outgrowths of the body surface or throat used for gas exchange in aquatic animals

what factors make gills efficient

they present an extremely large surface area for oxygen to diffuse across an extremely thin epithelium

how do fish breathe

through its gills with a COUNTERcurrent flow

How does countercurrent exchange work tomaximize the amount of oxygen taken up by gills

contracts O2, it ensures that the difference in the amount of O2 and CO2 in water vs. blood is large over the entire respiratory surface

how does the tracheae work in insects

they form an expense system of tubes located well within the insect body

what are spiracles

an external respiratory opening

How might muscle activity ventilate tracheae

humans and other mammals ventilate their lungs by increasing their lung volume by expanding their thoracic cavity to draw oxygen rich air into the lungs and reduce their lung volume to expire oxygen-poor air from the lungs

what is tidal ventilation

intercostal muscles and the diaphragm contract, the net effect is that the chest cavity becomes larger which reduces air pressure in the lungs

Why is the Po2 only 100 mm inour lung when air Po2 is 160

because once the diaphragm contracts, the diaphragm moves down and the ribs move out. this lowers the negative pressure in the chest cavity. as the pressure surrounding the lungs drops, the lungs expand and air flows in along the pressure gradient

What is a typical ventilation rate at rest

12-20 breaths per minute

What are the parts of the human lung

trachea


bronchi


bronchioles


alveoli

where is gas exchanged

alveoli

how is gas exchanged

air passes through the larynx


larynx to trachea


trachea into bronchi


bronchi into bronchioles


bronchioles into alveoli which greatly increase the surface area for gas exchange

How does the bird respiratory system work

1. draws oxygen-rich air into posterior air sacs


2. exhalation moves fresh air into lung


3. second inhalation moves stale oxygen depleted air from lung into anterior air sacs


4. second exhalation moves air out of anterior air sacs

Whatadvantages does this system have

bird lungs are rigid (don't inflate or deflate)


air flow is unidirectional, allowing for a larger (P2-P1)


birds are able to extract enough O2 for extremely long flights and flights at high elevation where PO2 is low

How is the bird respiratory system different from ours

-birds have a continuous supply of fresh air in both inhalation and exhalation


-birds have air sacs


-birds do not have a diaphragm


-bird lungs do not contract or expand

how is breathing rate controlled

by chemoreceptors in the medullary respiratory system in the brain stem set the respiratory rhythm

what signal is sensed

sensors detect drop in O2 levels and an increase in Co2 levels

what part of the nervous system is the effector

the diaphragm and other respiratory muscles

how does it generate a response?

diaphragm/muscles contract more frequently and more strongly

Why do we need a molecule like hemoglobin to transportO2

because hemoglobin is able to bind to the oxygen molecules


How does hemoglobin transport O2

by attaching each iron ion to an individual oxygen molecule

What shape does the oxygen-hemoglobin equilibrium curvehave

increasing in a backwards s shape

Why does it have this shape

because in the middle of the curve, small increases (or decreases) in Po2 result in large increases (or decreases) in hemoglobin saturation

How do temperature and pH affect oxygen binding tohemoglobin

by the bohr shift

What is the Bohr shift

decreases in pH and increases in temperature alter hemoglobin conformation to make it more likely to release o2 at all Po2 levels

How does fetal hemoglobin differ from hemoglobin of themother

the fetus's hemoglobin allows the fetus to take in O2 from the mothers circulation

why is this a good thing

this is a good thing because the fetus is able to get its supply of oxygen

What types of animals typically have open circulatory systems

insects and many mollusks including clams

what are the characteristics of open circulatory systems

-blood flows through a vessel with muscular thickenings that act as a pump


-blood empties into an open body cavity to supply the tissues with nutrients and is returned to the circulation

what are the characteristics of a closed circulatory system

-blood flows through connected blood vessels


-pumped by muscular hearts


-the blood flows through vessels to supply tissues with nutrients

what types of animals have closed circulatory systems

larger animals, vertebrates, earthworms, squid, octopus

what is one advantage of an open circulatory system

molecules do not have to diffuse across blood vessels to get to tissues

what is one advantage of a closed circulatory system

blood flow can be directed in a precise way. regulatory systems can shun blood to specific vessels and thus to specific locations

How do we maintain blood flow through the circuitand still have gas exchange

-blood leaves arteries with high flow rate because of low resistance due to large diameter vessels


-number of capillaries is large, making total cross sectional are large


-this effects the increased resistance to maintain blood flow through the circuit

what is an artery

-large, high pressure vessels that carry blood away from the heart


-walls are tough/thick, containing muscle and elastic layers composed of elastin and collagen

what are veins

-carry deoxygenated blood back to the heart.


-because blood pressure is relatively low, veins have much thinner walls and much larger interior diameters than arteries

what are capillaries

-smalles, thinnest vessels


-walls are 1 cell layer thick, allowing blood and other tissues in dense networks called capillary beds

what is hemolymph

an invertebrates equivalent to blood

what is lymph

a colorless fluid containing white blood cells, that bathes the tissues and drains through the lymphatic system into the bloodstream

where does lymph come from

from blood vessels that flow throughout the body

where does lymph go

back into the blood

How does blood flow in the fish circulatory system

1. deoxygenated blood enters the atrium from a main vein and is pumped into the ventricle


2. deoxygenated blood is pumped from the ventricle into a main artery



what is a disadvantage of the fish circulatory system

much of the blood pressure is lost moving across small capillaries in the gills. This limits the flow of oxygenated blood to body tissues

How does blood flow in the mammalian circulatorysystem

1. deoxygenated blood enters the right atrium from the inferior and superior venae cavae


2.deoxygenated blood passes through the right AV valve and enters the right ventricle


3. deoxygenated blood is pumped into the pulmonary arteries through the pulmonary valve


4. oxygenated blood returns from the lungs to the left atrium


5. oxygenated blood enters the left ventricle through the left ventricle through the left AV valve


6. oxygenated blood is pumped by the left ventricle through the aortic valve into the systemic circulation

in what parts of the heart is blood oxygenated

left atrium


left ventricle



what are the 2 phases of the cardiac cycle

pulmonary and systemic circuit

what happens during the pulmonary circuit

1. oxygen depleted blood enters the right atrium


2. when the right atrium contracts, the deoxygenated blood moves through an AV valve into right ventricle


3. right ventricle contracts and sends deoxygenated blood through the pulmonary valve to the lungs via pulmonary arteries


4. once blood has circulated through the capillary beds in the lungs and alveoli and become oxygenated, it returns to the heart to the left atrium

what happens during the systemic circuit

1.left atrium contracts sending oxygenated blood through the left AV valve to the left ventricle


2. left ventricle contracts sending oxygenated blood through the aortic valve