Biopsychosocial Perspecitve

Front 1

Genetic Disorders

Back 1

Produce non-specific mental retardation
Schiz. familial inheretance but not Mendellian

Front 2

Gentic Disorders
Lesch-Nayn

Back 2

profound mental retardation
self mutilation - bite lips
deficiency of hypoxanthine-guaninephosphoribosyltransference

Front 3

Gentic Disorders
Prader-Willi

Back 3

mildy retarded, increased appetites and obesity. Must lock fridge.
15q deletion

Front 4

Gentic Disorders
Homocysteinuria

Back 4

~15% develop schitz. (less than 1% in normal pop.)
cystathionine beta synthase deficiency

Front 5

Gentic Disorders
Cardio-velo-facial syndrome

Back 5

Can develop Schiz or other disorders
Cardiac and Midface abnormalitites
NOT retarded
22q11

Front 6

Major Receptors
Serotonin
5HT 1A

Back 6

AC-
antidepressant, anxiolytic

Front 7

Major Receptors
Serotonin
5HT 2A

Back 7

target of hallucinogens,
atypical antipsychotics
PI

Front 8

Major Receptors
Dopamine
D2

Back 8

antipsychotics work here
Side effects
AC-

Front 9

Major Receptors
Cholinergic
M1

Back 9

congition and seizures, PI

Front 10

Major Receptors
Cholinergic
M4

Back 10

antiparkinsonian drugs
ac-

Front 11

Major Receptors
Cholinergic
NAChR

Back 11

tobacco use, cognitive enhancement

Front 12

Major Receptors
Andrenergic
alpha 2 A,B,C

Back 12

agonists sedative and antihypertension

Front 13

Major Receptors
Histamine
H1

Back 13

antagonists produce sedatation, weight gain
are side effects

Front 14

Neurotransmitter
Norepi

Back 14

Alertness, consciousness, energy

Front 15

Neurotransmitter
serotonin

Back 15

mood, obcession/complusion
aggression and suiside from lack of serotonin

Front 16

Neurotransmitter
Dopamine

Back 16

reward (addiction)

Front 17

Neurotransmitter
Increased and Decrease Dopamine and norepi

Back 17

Inc: Mania
Dec: Depression

Front 18

AA Neurotransmitters
Inhibitory
GABA

Back 18

Cl- Channels
benzodiazepine
Barbituates
Alcohol

Front 19

AA Neurotransmitters
Inhibitory
Glycine

Back 19

Involved in Schiz.

Front 20

AA Neurotransmitters
Excitatory
Glutamate

Back 20

Memory, also schiz.

Front 21

Neuropeptides
Opiods

Back 21

endorphine, PAIN, hunger, huirst, mood

Front 22

Neuropeptides
Corticotrophin Releaseing Factor (CRF)

Back 22

stress response

Front 23

Neuropeptides
Substance P

Back 23

mediate pain

Front 24

Neuropeptides
Neurotensin

Back 24

needed for full response to some antipsychotics

Front 25

Neuropeptides
Cholecystokinin

Back 25

mediates satiety

Front 26

Neuropeptides
Vasopressin/Oxytocin

Back 26

Social Bonding

Front 27

Neuropeptides
Neuropeptide Y

Back 27

increased levels during chronic stress
(fat accumulation)

Front 28

Cytokine Overproduction

Back 28

Can lead to disease

Front 29

Cytokine IL-1 and TNF alpha

Back 29

lead to destruction of rheumatoid arthritis.

Front 30

Actions of Frontal Lobe

Back 30

vol. movement
lang production (left)
motor prosody (right)
comportment
executive fxn
motivation

Front 31

Actions of Temporal Lobe

Back 31

audition
Lang. coimprehension (left)
sensory prosody (right)
memory
emotion

Front 32

Temporal Lobe Epilepsy

Back 32

Hallucinations; psychotic episodes with or without memory

Front 33

Bilat. T. Lobe Damage

Back 33

hypersexuality, placidity, tendency to explore env. with mouth (spak syndrome), shift attn', no emotion behind stimuli (can't tell angry v. happy)

Front 34

Parietal Lobes

Back 34

tactile sensation
visuospatial fxn (right)
reading (left)
calculation (left)
Body Parts and spatial relation, neglect

Front 35

Limbic System
Hypothalamus

Back 35

hunger, thirst, levels of pleasure, anger and aggression

Front 36

Limbic System
Hippocampus

Back 36

short and long term memory

Front 37

Limbic System
Amygdala

Back 37

integrating internal and external stimuli
learned fear response (anxiety or panic)

Front 38

Ventral Tegmental Area

Back 38

dopamine pathway
pleasure and addiction

Front 39

Cingulate Gyrus

Back 39

focuses attn on emotionally significant events

Front 40

Basal Ganglia

Back 40

repetitive behaviors, reward experiences

Front 41

Basal Ganglia
Caudate

Back 41

Motor Acts
Malfunction leads to OCD, also Huntinton's and tourette's.

Front 42

Basal Ganglia
Putamen

Back 42

movement; learning

Front 43

Basal Ganglia
Globus Pallidus

Back 43

postural control
Affected in Wilson's disease, Copper interacts with

Front 44

Basal Ganglia
Substantia Nigra

Back 44

degeneration causes Parkinson's

Front 45

Prefrontal Cortex

Back 45

thinking about future. exec. fxn

Front 46

ANS
Sympathetic

Back 46

Activated by cocaine, amphetamine
and withdrawls of sedatives (alcohol, opioids, benzo)

Front 47

Arcuate Fasculus

Back 47

Connect Broac's Area to Wiernikes, damage leads to conduction aphasia