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69 Cards in this Set

  • Front
  • Back
What are the 3 functional units of brain organization?

Who came up with them?
What do they regulate?
First Functional Unit
Second Functional Unit
Third Functional Unit

Luria
They regulate sleep/waking
What is the First Functional Unit
Structures that regulate/maintain optimal cortical tone (sleep/waking processes, levels of arousal, attention)
What is the 2nd Functional Unit of Luria's for sleep/waking?
Structures & processes assoc w/acquisition & retention of info (sensation, perception, memory)
What is the 3rd Functional Unit of Luria's for sleep/waking?
Structures & processes assoc w/initiation, regulation, & verification of Bx
Which is NOT true about sleep:
a. fluctuates in activity, brain/body interactions
b. is an active process
c. is taken for granted
d. stops once you are awake
d. fundamental sleep/arousal systems are involved in all waking processes. Arousal underlies all aspects of brain and psych functioning
What is Optimal Cortical Tone
a person's ideal degree of alertness for a given task

Described by Luria

First functional unit
Which of the below is (are) true about normal sleep?
a. Sleep should be btwn 6-13 hrs
b. SOL is <30
c. Sleep is subjectively satisfying
d. Sleep architecture stays the same across the lifespan
e. abc
f. all of the above
e. Sleep architecture changes across the niht & across the course of development & maturation
What is Sleep Onset Latency?
the average amount of time it takes someone to fall asleep on most nights. It is less than 30 min
What does the sleep state represent?
A great effort by the nervous system, metabolism, and synchrony.
What is one of the vegetative signs of most of the major Axis I & II pathologies?
Sleep disturbances
What is the easiest measure of sleep quality?
EEG
How many stages of NON-REM sleep are there?
4
What occurs during NREM Stage I?
5 minutes long

The brains decision to progress to deeper sleep; ends w/complete disconnection of sensory awareness
What occurs during NREM Stage II?
subjective sleep; brain's effort to establish & maintain sleep

EEG shows Phasic Phenomena

- assoc w/either no mental activity or incomplete, disjointed mentations
What occurs during NREM Stage III?
Beginning of deep, slow wave sleep. Proportional to the amount of physical effort exerted during the day.
- part of deep electrographic sleep
-assoc w/no or minimal mental activity
Describe Stage IV of NREM?
deep, slow wave sleep
-like Stage III it is proportional to daily physical activity & assoc w/no mental activity
What is an Epoch of EEG?
30sec; a unit of time of EEG activity

-based on time for paper to pass 1 page of EEG paper
What are alpha waves?
predominantly from occipital lobe; state of relaxation.
-can be experienced by advanced meditators when they are meditating
- REM sleep
What are theta waves? What sleep stages do you see these in?
>50% - Stage 1 NREM
>50% & no alpha - Stage II
Some in Stage III
What is a K Complex?
Stage II sleep; part of phasic phenomena

consistent clusters of activity in EEG
What are sleep spindles? What phase do they appear in?
Stage II w/k complexes
What is the Phasic Phenomena?
Sleep spindles & k-complexes
What is the difference between NREM stage 1 & 2 and 3&4?
3&4 are restorative because they have more delta (big slow waves)
What is the EEG montage?
The array of electrodes on the scalp.
Describe Stage IV of NREM?
deep, slow wave sleep
-like Stage III it is proportional to daily physical activity & assoc w/no mental activity
What does the EEG tell you about sleep?
car exhaust. It is vague but reps some function of cortical & subcortical activity
What are theta waves? What sleep stages do you see these in?
>50% - Stage 1 NREM
>50% & no alpha - Stage II
Some in Stage III
Describe Stage IV of NREM?
deep, slow wave sleep
-like Stage III it is proportional to daily physical activity & assoc w/no mental activity
What are sleep spindles? What phase do they appear in?
Stage II w/k complexes
What is the Phasic Phenomena?
Sleep spindles & k-complexes
What is the difference between NREM stage 1 & 2 and 3&4?
3&4 are restorative because they have more delta (big slow waves)
What are theta waves? What sleep stages do you see these in?
>50% - Stage 1 NREM
>50% & no alpha - Stage II
Some in Stage III
Which stages of sleep are associated with various parasomnias?
Stages of III & IV NREM
On an EEG, what does Stage IV sleep pattern resemble?
a coma
What do a lot of PGO spikes and Saw Tooth Waves show?
Dreaming during REM sleep
What does Emergent Stage I REM sleep look like on EEG?
alpha and beta activity w/saw-tooth waves and PGO spikes
How long are REM episodes? Do they change?
They change throughout the night; start at 5 minutes and end at 20 minutes.

Occur in 90 min intervals
What does REM sleep reflect?
-amount of cognitive activity from the day
-exposure to new kinds of info
-memory processes (consolidation & removal of old stuff)
-protein synthesis & synaptogenesis
What is a REM Intrusion?
an indication of sleep deprivation
What part of the brain is off during REM sleep?

What might this explain?
prefrontal cortex (volition, morality, intention, etc)

-may explain why dreams are disorg & illogical
Motor activity during EEG REP sleep - is it possible?
Yes but it may reflect a pathological (or abnormal) condition
What is REM rebound?

How do we usually interpret them?
a mini-withdrawal; shows you can experience w/drawal from a REM blocker after one dose (such as alcohol)

-features inc'd length & freq of REM episodes

-usually interpreted as a nightmare
Who gets more REM - an infant or a teenager?
Infant (especially 3 &4)
What are the greatest enemies of sleep?
Age (starting at 25, then 45, then 65)
Sleep Deprivation
Drugs
Pain/Illness
Lifestyle
At what ages are parasomnias considered more normal?
3 & 4
What are the biological mechanisms behind sleep?
Ascending Reticular Activating System (ARAS)
and 5HT, ACh, and GABA
What is the ARAS?
Ascending Reticular Activating Systems
What is the MRF?
Mesencephalic Reticular Formation; Source of arousal

Connected with the Locus Coeruleus
What is the LC?
Locus Coeruleus; source of NEPI norepinephrine
What is the order of the ARAS?
brain arousal = MRF-->LC-->DTS --> cortex-->anterior cortex -->MyRF-->RN-->MRF

Body arousal = MRF --> LC-->PH-->adrenals
What is the DTS?
crossroads of everything in the brain; sends stimulation to everything in the cortex
-Diffuse Thalamic System aka Intrinsic thalamic nuclei
How do you wake up?
Diffuse Thalamic System sends out excitation to all of the cortex
Anterior Cortex (cingulate gyrus, frontal lobesk, basal forebrain)
-monitors level of arousal
-if you wake up & feel wide awake, this sends message to posterior MRF (myelencephalic reticular formation)
Raphe Nucleus
source of serotonin in the brain

- gets a signal from posterior MRF and this either inhibits or dishibits the MRF to wake you up
The Locus Coeruleus activates the posterior hypothalamus in ARAS- what does this accomplish?
Adrenaline and the wakening of your body
What happens during sleep paralysis?

Sleep walking?
ARAS activated your DTS but not the posterior hypothalamus

The reverse
What are the types of apneas?
Obstructive
Central
Mixed
Cheyne-Stokes
SID (Hering-Breuer reflex)
What is nocturnal myoclonus?
-actual movement while falling asleep (commonly kicking)
What is one cause for ADD diagnosis?
A kid w/apnea - doesn't get sleep
What neurochemical keeps the cortex under inhibitory control during NREM sleep?
a. 5HT
b. GABA
c. ACh
d. None of the above
a.
5HT inhibits the NEPI system to maintain slow wave sleep in NREM
Which chemical reduces inhibition to cortex and marks onset of REM sleep? This one also marks the end of REM sleep to bring back a slow wave pattern.
a. GABA
b. Serotonin
c. Adrenalin
d. Acetylcholine
d. ACh
What takes over to maintain sleep state in the cortex during REM?
a. 5HT
b. GABA
c. ACh
d. GABA blockers
b. after ACh has reduced inhibition of 5HT in the cortex, GABA takes over
What neurochemical appears to be necessary for REM phenomena (saw tooth waves & PGO Spikes) and conscious dreams?
GABA
What blocks conscious dreams, PGO Spikes, saw tooth waves, and REM?
a. GABA
b. ACh
c. GABA blockers
d. Adrenalin
c. gaba blockers
Which type of insomnia are anxiety disorders linked with?
a. onset
b. maintenance
c. early morning waking
d. obstructive
a. onset
Which type of insomnia are ruminative/worry disorders linked with?
a. onset
b. maintenance
c. early morning waking
d. mixed
maintenance, b
Which type of insomnia are depressive disorders linked with?
a. onset
b. maintenance
c. early morning waking
d. central
early morning waking, c
__a____ time sets the clock better than ___b___ time in circadian rhythm disorders

options: sleeping, waking, bed
a- waking
b- sleeping
What is the one medication that can induce natural sleep?
a. Valerian
b. diphenhydramine
c. Luminal
d. Rozerem
d. stimulates melatonin receptors, which triggers natural sleep process w/almost no side effects, slow development of tolerance, and little/no dependence