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16 Cards in this Set
- Front
- Back
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what is compliance with respect to blood vessels
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ability to expand or contract passively due to changes in pressure
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why are arteries compliant?
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they can withstand changes in arterial pressure
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define artherosclerosis
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fatty deposits along walls of the arteries
-leads to blockage |
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what are the 3 main sites for artherosclerosis
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coronary artery
peripheral artery carotid artery |
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what are the 8 major risk factors for artherosclerosis
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high cholesterol
smoking family hx diabetes obesity age HTN inactivity |
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Describe AAA (aneurysm)
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abnormal expanding, widening, bulging of an artery that is weak
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what are the major risk factors of AAA that are different from artherosclerosis
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gender
tuberculosis syphilis |
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what are the 3 primary polymers used to make synthetic vascular grafts
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Dacron
ePTFE PU (polyurethane) |
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how does heparin affect ePTFE grafts
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reduces thrombogenicity
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how does growth factor affect ePTFE grafts (2)
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enhances endothelialization
vascular healing |
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what are design criteria for synthetic vascular graft (11)
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match dimensions of native vessel
compliance biocompatibility lack of chemical reactivity low thrombogenicity porosity sterility flexibility resist kinking/squashing strength similar to native vessel |
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define patency
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unblocked, open, expanded
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how does graft diameter impact patency rates
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increased diameter increases patency
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how does porosity impact vascular graft properties
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larger pore size promotes tissue ingrowth and compliance
-larger pore size is desirable |
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define intimal hyperplasia
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thickening of the tunica intima of a blood vessel
(inner most layer of vein/artery) |
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define endoleak
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flow of blood outside the lumen (into the aneurysm or adjacent graft) due to incomplete sealing
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