Biology Of The Mind - Neurotransmitter Receptor Part2

Front 1

What are the 2 main types of neurotransmitter receptor?

Back 1

Ligand-gated ion channels
G-protein-coupled receptors

Front 2

The subunits of iontropic receptors are either...(2)

Back 2

a 4 transmembrane helices or a 3 transmembrane plus pore loop

Front 3

The nicotinic acetylcholine receptors has __ different subunit

Back 3

5

Front 4

The nicotinic acetylcholine receptor has a ________ structure with a channel

Back 4

pentomeric

Front 5

The nicotinic acetylcholine receptors are permeable to which ions?

Back 5

Na+
K+
Ca2+ (sometimes)

Front 6

AMPA is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)

Back 6

4-transmembrane helices

Front 7

NMDA is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)

Back 7

4- transmembrane helices

Front 8

Kainate is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)

Back 8

4 transmembrane helices

Front 9

GABA is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)

Back 9

Pentamer

Front 10

Glycine is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)

Back 10

Pentamer

Front 11

nACh is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)

Back 11

pentamer

Front 12

Serotonin is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)

Back 12

pentamer

Front 13

Purine is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)

Back 13

3 transmembrane plus pore loop

Front 14

What is the co-agonist to glutamate that binds to NMDA receptor?

Back 14

glycine

Front 15

NMDA is permeable to which ions?

Back 15

Na+ K+ and Ca2+

Front 16

The NMDA is activated by a weak stimulation (True/False)

Back 16

False NMDA is only active during high frequency stimulation

Front 17

Which ions blocks the NMDA receptor during resting potential?

Back 17

Mg2+

Front 18

How many subunit does the GABAa receptor have?

Back 18

5

Front 19

GABA binds to which subunit in the GABAa receptor?

Back 19

beta

Front 20

Which ion is permeable to the GABAa receptor

Back 20

Chloride ions

Front 21

Which molecules inhibits the flow of chloride ions into the cell

Back 21

Picotoxin

Front 22

What drugs are able to bind to the GABAa receptor?

Back 22

Benzodiazepine
Barbiturates
Steroids
Picotoxin

Front 23

How many domains does the metabotropic receptor have?

Back 23

7

Front 24

G proteins binds to loop between domains ___ and ___ and to portions of the C terminus

Back 24

5 and 6

Front 25

Metabatropic receptors are G-protein coupled receptors (True/False)

Back 25

True

Front 26

Dopamine binds to ligand-gated ion channels (True/False)

Back 26

False dopamine binds to G-protein coupled receptors

Front 27

Which receptor does noradrenaline bind to?

Back 27

Beta-adrenergic receptor

Front 28

Glutamate is able to bind with which 2 receptors?

Back 28

mGLuR1 and mGLuR2

Front 29

mGLuR1 is coupled with (Gq/Gi)

Back 29

Gq

Front 30

mGLuR2 is coupled with (Gq/Gi)

Back 30

Gi

Front 31

Glutamate binding to (mGLuR1/mGLuR2) will cause an increase in protein phosphorylation and activates calcium-binding proteins

Back 31

mGLuR1

Front 32

Glutamate binding to (mGLuR1/mGLuR2) will cause a decrease in protein phosphorylation

Back 32

mGLuR2

Front 33

(Gq/Gi) will stimulate phospholipase C

Back 33

Gq

Front 34

(Gq/Gi) will inhibit Adenylyl cyclase

Back 34

Gi

Front 35

Noradrenaline binding to beta-adrenergic receptor will cause what at the target protein?

Back 35

Increase protein phosphorylation