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35 Cards in this Set

  • Front
  • Back
What are the 2 main types of neurotransmitter receptor?
Ligand-gated ion channels
G-protein-coupled receptors
The subunits of iontropic receptors are either...(2)
a 4 transmembrane helices or a 3 transmembrane plus pore loop
The nicotinic acetylcholine receptors has __ different subunit
5
The nicotinic acetylcholine receptor has a ________ structure with a channel
pentomeric
The nicotinic acetylcholine receptors are permeable to which ions?
Na+
K+
Ca2+ (sometimes)
AMPA is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)
4-transmembrane helices
NMDA is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)
4- transmembrane helices
Kainate is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)
4 transmembrane helices
GABA is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)
Pentamer
Glycine is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)
Pentamer
nACh is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)
pentamer
Serotonin is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)
pentamer
Purine is a (4-transmembrane helices/pentamer/3-transmembrane plus pore loop)
3 transmembrane plus pore loop
What is the co-agonist to glutamate that binds to NMDA receptor?
glycine
NMDA is permeable to which ions?
Na+ K+ and Ca2+
The NMDA is activated by a weak stimulation (True/False)
False NMDA is only active during high frequency stimulation
Which ions blocks the NMDA receptor during resting potential?
Mg2+
How many subunit does the GABAa receptor have?
5
GABA binds to which subunit in the GABAa receptor?
beta
Which ion is permeable to the GABAa receptor
Chloride ions
Which molecules inhibits the flow of chloride ions into the cell
Picotoxin
What drugs are able to bind to the GABAa receptor?
Benzodiazepine
Barbiturates
Steroids
Picotoxin
How many domains does the metabotropic receptor have?
7
G proteins binds to loop between domains ___ and ___ and to portions of the C terminus
5 and 6
Metabatropic receptors are G-protein coupled receptors (True/False)
True
Dopamine binds to ligand-gated ion channels (True/False)
False dopamine binds to G-protein coupled receptors
Which receptor does noradrenaline bind to?
Beta-adrenergic receptor
Glutamate is able to bind with which 2 receptors?
mGLuR1 and mGLuR2
mGLuR1 is coupled with (Gq/Gi)
Gq
mGLuR2 is coupled with (Gq/Gi)
Gi
Glutamate binding to (mGLuR1/mGLuR2) will cause an increase in protein phosphorylation and activates calcium-binding proteins
mGLuR1
Glutamate binding to (mGLuR1/mGLuR2) will cause a decrease in protein phosphorylation
mGLuR2
(Gq/Gi) will stimulate phospholipase C
Gq
(Gq/Gi) will inhibit Adenylyl cyclase
Gi
Noradrenaline binding to beta-adrenergic receptor will cause what at the target protein?
Increase protein phosphorylation