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12 Cards in this Set

  • Front
  • Back

penetration of drugs into central nervous system

drug must pass through blood brain barrier to affect the brain

ways drugs can affect the brain

1. bind to a receptor


2. influencing synthesis, transport, and releae of a neurotransmitter


3. influencing deactivation of a neurotransmitter (eg reuptake of neurotransmitter

drug metabolism

drugs made into non active forms by enzymes


1. usually enzymes produced by liver


2. usually now can't pass through blood brain barrier


3. some passed by urine, breath, sweat, feces, mothers milk--used for drug tests

drug tolerance

1. decreased sensitivity to a drug that develops as a result of exposure to the drug


2. a shift in dose response curve

tests of drug tolerance

1. same amount of drug has less effect with repeated use


2. takes more of the same drug to get same effect with repeated use

dose response curve



graph of size of effect of drug with different doses. has many uses

tobacco

1. leading cause of preventable deaths worldwide


2. nicotine


3. tar

nicotine

major psychactive ingredient in tobacco. affects nicotinic cholinergic (acetylcholine) receptors of the brain

tar

collective term for other chemicals in tobacco

tobacco addiction

show tolerance


1. first cigarette often unpleasant experience

unpleasant symptoms of first cigarette

1. coughing


2. nausea


3. sweating


4. dizziness


5. cramps


6. flushing

cigarette smokers symptoms

1. report more relaxed, alert, less hungry after smoking


2. craving for cigarette