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25 Cards in this Set

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  • Back
Found in grey matter and hippocampi?
Tangles
Product of hyper P Tau?
Tangles
Insoluble, paired helical filaments which disrupt transport axons?
Tangles
RIsk factors for tangles?
Boxers
Aging
What is beta-amyloid synthesised from?
Amyloid precursor proteins (APP)
Derived from gene on chromosome 21?
APP
Which enzymes produce beta-amyloid proteins from APP?
Beta-secretase
Gamma-secretase
Where are Lewy Bodies found in PD?
Substantia nigra
Where are Lewy Bodies found in LDB?
Cerebral cortex
What do Lewy Bodies consist of?
Ubiquitin and alpha-synuclein
Where is APP mutation in hereditory early onset Alzheimer's?
Chromosomes 1 and 14 (Presenilin)
Is Alzheimer's more commonly hereditory or sporadic?
Sporadic
Where is Presenilin 1 found?
Chromosome 14
Where is Presenilin 2 found?
Chromosome 1
What does apolipoprotein E bind to?
Tau and Amyloid
Which chromosome is gene for apolipoprotein E found on?
Chromosome 19
What is Apo E4 associated with?
Earlier onset of typical late-onset Alzheimers
Apo E4 determines whether or not one develops Alzheimer's.
T/F?
F - determines when, not whether, one develops it
What % of patients with Azheimer's don't have Apo E4?
40%
Apo E2 is neurodegenerative.
T/F?
F - Neuroprotective
In familial AD there is no mutation Tau gene.
T/F
T
Increase of plaques/tangles leads to an increase of ACh.
T/F?
F - More plauqes/tangles; Less ACh
Name 3 common ACh-esterase inhibitors.
Donepezil (Aricept)
Rivastigmine (Exelon)
Galantamine (Reminyl)
ACh-esterase inhibtors may be used in which dementias?
AD
LBD
Vascular
What is Memantine?
NMDA antagonist
Used in moderate-severe AD
Anti-excitatroy