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25 Cards in this Set
- Front
- Back
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Found in grey matter and hippocampi?
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Tangles
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Product of hyper P Tau?
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Tangles
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Insoluble, paired helical filaments which disrupt transport axons?
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Tangles
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RIsk factors for tangles?
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Boxers
Aging |
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What is beta-amyloid synthesised from?
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Amyloid precursor proteins (APP)
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Derived from gene on chromosome 21?
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APP
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Which enzymes produce beta-amyloid proteins from APP?
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Beta-secretase
Gamma-secretase |
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Where are Lewy Bodies found in PD?
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Substantia nigra
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Where are Lewy Bodies found in LDB?
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Cerebral cortex
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What do Lewy Bodies consist of?
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Ubiquitin and alpha-synuclein
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Where is APP mutation in hereditory early onset Alzheimer's?
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Chromosomes 1 and 14 (Presenilin)
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Is Alzheimer's more commonly hereditory or sporadic?
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Sporadic
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Where is Presenilin 1 found?
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Chromosome 14
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Where is Presenilin 2 found?
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Chromosome 1
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What does apolipoprotein E bind to?
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Tau and Amyloid
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Which chromosome is gene for apolipoprotein E found on?
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Chromosome 19
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What is Apo E4 associated with?
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Earlier onset of typical late-onset Alzheimers
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Apo E4 determines whether or not one develops Alzheimer's.
T/F? |
F - determines when, not whether, one develops it
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What % of patients with Azheimer's don't have Apo E4?
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40%
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Apo E2 is neurodegenerative.
T/F? |
F - Neuroprotective
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In familial AD there is no mutation Tau gene.
T/F |
T
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Increase of plaques/tangles leads to an increase of ACh.
T/F? |
F - More plauqes/tangles; Less ACh
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Name 3 common ACh-esterase inhibitors.
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Donepezil (Aricept)
Rivastigmine (Exelon) Galantamine (Reminyl) |
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ACh-esterase inhibtors may be used in which dementias?
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AD
LBD Vascular |
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What is Memantine?
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NMDA antagonist
Used in moderate-severe AD Anti-excitatroy |
